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Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic
Li, HX(李海霞); Liu, YC; Tang, RZ(唐壑智); Zhang, P(张鹏); Fu, HY(付海英); Yao, SD(姚思德); Wang, WF(王文锋)
2012
Source PublicationSCIENCE CHINA-CHEMISTRY
ISSN1674-7291
Volume55Issue:7
AbstractThe reactions between gatifloxacin (GFX) and various one-electron oxidants, such as (OH)-O-center dot, N-3 (center dot), Br-2 (center dot-), and SO4 (center dot-), have been studied by pulse radiolysis techniques. The GFX radical anion formed in the reaction of GFX with e(aq) (-) could either be protonated or deprotonated, and the absorption of GFX radical anion was located at 390 nm. The transient species produced by the reaction of GFX with (OH)-O-center dot radical shows a broad band in the 380-600 nm region with a shoulder, while the oxidation by N-3 (center dot), SO4 (center dot-), and Br-2 (center dot-) results in an absorption band with lambda (max) = 370 nm. At neutral condition (pH 7), the rate constants of GFX reacting with (OH)-O-center dot, N-3 (center dot), Br-2 (center dot-), SO4 (center dot-) and e(aq) (-) are estimated to be 1.0 x 10(10), 3.1 x 10(9), 2.8 x 10(9), 3.0 x 10(9), and 1.8 x 10(10) dm(3) mol(-1) s(-1), respectively. From the pH dependence on the formation of electron adducts and on the rate constant of GFX with e(aq) (-), the pK(a) of GFX radical anion is estimated to be 5.5 and 9.3.
Language英语
Funding Project应物所项目组
WOS IDWOS:000306070500023
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13266
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, HX,Liu, YC,Tang, RZ,et al. Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic[J]. SCIENCE CHINA-CHEMISTRY,2012,55(7).
APA Li, HX.,Liu, YC.,Tang, RZ.,Zhang, P.,Fu, HY.,...&Wang, WF.(2012).Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic.SCIENCE CHINA-CHEMISTRY,55(7).
MLA Li, HX,et al."Pulse radiolysis study on gatifloxacin - A fluoroquinolone antibiotic".SCIENCE CHINA-CHEMISTRY 55.7(2012).
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