CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression
Ma, YF; Yu, JF(于俊峰); Wang, C; Shen, H(沈华); Wu, H
2012
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
Volume23Issue:1
AbstractIntegrin alpha(v)beta(3), a cell adhesion molecule, plays a key role in angiogenesis and tumor cell metastasis and is therefore an important target for new therapeutic and diagnostic strategies. Since ROD bind to alpha(v)beta(3) particularly, a lot of ROD containing peptides were radiolabeled and evaluated as imaging or therapeutic agents. In this study, a new Re-188-RGD peptide analog was synthesized and characterized. Within 30 min, the Re-188-H-E[c(RGDyK)](2) was obtained in radiochemical purity of better than 95%. The His-E[c(RGDyK)](2) had a good integrin-binding affinity (50% inhibitiory concentracer (IC50=46.5x10(-9) nm) and exhibited active accumulation (7.20 +/- 1.06) in S180 tumor. Because of relatively fast washout in blood and normal tissues, the target/non-target ratio was high. Further experiments to improve the tumor targeting efficacy and in vivo kinetic profiles are in progress towards developing it into a promising radio agent.
Language英语
Funding Project应物所项目组
WOS IDWOS:000303971000009
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13274
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Ma, YF,Yu, JF,Wang, C,et al. Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression[J]. NUCLEAR SCIENCE AND TECHNIQUES,2012,23(1).
APA Ma, YF,Yu, JF,Wang, C,Shen, H,&Wu, H.(2012).Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression.NUCLEAR SCIENCE AND TECHNIQUES,23(1).
MLA Ma, YF,et al."Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression".NUCLEAR SCIENCE AND TECHNIQUES 23.1(2012).
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