Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression | |
| Ma, YF; Yu, JF(于俊峰); Wang, C; Shen, H(沈华); Wu, H | |
| 2012 | |
| Source Publication | NUCLEAR SCIENCE AND TECHNIQUES
 |
| ISSN | 1001-8042 |
| Volume | 23Issue:1 |
| Abstract | Integrin alpha(v)beta(3), a cell adhesion molecule, plays a key role in angiogenesis and tumor cell metastasis and is therefore an important target for new therapeutic and diagnostic strategies. Since ROD bind to alpha(v)beta(3) particularly, a lot of ROD containing peptides were radiolabeled and evaluated as imaging or therapeutic agents. In this study, a new Re-188-RGD peptide analog was synthesized and characterized. Within 30 min, the Re-188-H-E[c(RGDyK)](2) was obtained in radiochemical purity of better than 95%. The His-E[c(RGDyK)](2) had a good integrin-binding affinity (50% inhibitiory concentracer (IC50=46.5x10(-9) nm) and exhibited active accumulation (7.20 +/- 1.06) in S180 tumor. Because of relatively fast washout in blood and normal tissues, the target/non-target ratio was high. Further experiments to improve the tumor targeting efficacy and in vivo kinetic profiles are in progress towards developing it into a promising radio agent. |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000303971000009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13274 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Ma, YF,Yu, JF,Wang, C,et al. Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression[J]. NUCLEAR SCIENCE AND TECHNIQUES,2012,23(1). |
| APA | Ma, YF,Yu, JF,Wang, C,Shen, H,&Wu, H.(2012).Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression.NUCLEAR SCIENCE AND TECHNIQUES,23(1). |
| MLA | Ma, YF,et al."Radiolabeling and evaluation of Re-188-RGD as an agent for alpha(v)beta(3) receptor expression".NUCLEAR SCIENCE AND TECHNIQUES 23.1(2012). |
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| File Name/Size | DocType | Version | Access | License | ||
| Radiolabeling and ev（799KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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