CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis
Su, S; Wei, XP; Zhong, YL; Guo, YY; Su, YY; Huang, Q(黄庆); Lee, ST; Fan, CH(樊春海); He, Y
2012
Source PublicationACS NANO
ISSN1936-0851
Volume6Issue:3
AbstractNanomaterial-based molecular beacons (nanoMBs) have been extensively explored due to unique merits of nanostructures, including gold nanoparticle (AuNP)-, carbon nanotube (CNT)-, and graphene-based nanoMBs. Those nanoMBs are well-studied; however, they possess relatively poor salt stability or low specificity, limiting their wide applications. Here, we present a novel kind of multicolor silicon-based nanoMBs by using AuNP-decorated silicon nanowires as high-performance quenchers. Significantly, the nanoMBs feature robust stability In high-concentration (0.1 M) salt solution and wide-ranging temperature (10-80 degrees C), high quenching efficiency (>90%) for various fluorophores (e.g., FAM, Cy5, and ROX), and large surfaces for simultaneous assembly of different DNA strands. We further show that silicon-based nanoMBs are highly effective for sensitive and specific multidetection of DNA targets. The unprecedented advantages of silicon-based multicolor nanoMBs would bring new opportunities for challenging bioapplications, such as allele discrimination, early cancer diagnosis, and molecular engineering, etc.
Language英语
Funding Project应物所项目组
WOS IDWOS:000301945900075
Citation statistics
Cited Times:83[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13288
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Su, S,Wei, XP,Zhong, YL,et al. Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis[J]. ACS NANO,2012,6(3).
APA Su, S.,Wei, XP.,Zhong, YL.,Guo, YY.,Su, YY.,...&He, Y.(2012).Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis.ACS NANO,6(3).
MLA Su, S,et al."Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis".ACS NANO 6.3(2012).
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