CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate
Cui, W; Zhang, YQ; Xu, XP; Shen, YM
2012
Source PublicationMEDICINAL CHEMISTRY
ISSN1573-4064
Volume8Issue:4
AbstractFolic acid receptors (FR) are usually over expressed in many cancer cells and are considered as potential targeted therapy agent. Generation of five polyamido amine (PAMAM) dendrimer folic acid conjugate was synthesised and radiolabelled with Re-188, furthermore the in vitro/in vivo stability was evaluated accordingly. The labelling yield of the conjugate G5-FA-DTPA-Re-188 was 67.1 % and its radiochemical purity exceeded 95 %. The conjugate also showed high in vitro stability and potential value for further structure modifications and evaluations.
Language英语
Funding Project应物所项目组
WOS IDWOS:000309524600027
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13306
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Cui, W,Zhang, YQ,Xu, XP,et al. Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate[J]. MEDICINAL CHEMISTRY,2012,8(4).
APA Cui, W,Zhang, YQ,Xu, XP,&Shen, YM.(2012).Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate.MEDICINAL CHEMISTRY,8(4).
MLA Cui, W,et al."Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate".MEDICINAL CHEMISTRY 8.4(2012).
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