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| Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate | |
| Cui, W; Zhang, YQ; Xu, XP; Shen, YM | |
| 2012 | |
| Source Publication | MEDICINAL CHEMISTRY
 |
| ISSN | 1573-4064 |
| Volume | 8Issue:4 |
| Abstract | Folic acid receptors (FR) are usually over expressed in many cancer cells and are considered as potential targeted therapy agent. Generation of five polyamido amine (PAMAM) dendrimer folic acid conjugate was synthesised and radiolabelled with Re-188, furthermore the in vitro/in vivo stability was evaluated accordingly. The labelling yield of the conjugate G5-FA-DTPA-Re-188 was 67.1 % and its radiochemical purity exceeded 95 %. The conjugate also showed high in vitro stability and potential value for further structure modifications and evaluations. |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000309524600027 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13306 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Cui, W,Zhang, YQ,Xu, XP,et al. Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate[J]. MEDICINAL CHEMISTRY,2012,8(4). |
| APA | Cui, W,Zhang, YQ,Xu, XP,&Shen, YM.(2012).Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate.MEDICINAL CHEMISTRY,8(4). |
| MLA | Cui, W,et al."Synthesis and Re-188 Radiolabelling of Dendrimer Polyamide Amine (PAMAM) Folic Acid Conjugate".MEDICINAL CHEMISTRY 8.4(2012). |
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| Synthesis and Re-188（722KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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