CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease
Wang, HJ; Wang, M; Wang, B; Li, M; Chen, HQ; Yu, XH(余笑寒); Zhao, YL; Feng, WY; Chai, ZF
2012
Source PublicationMETALLOMICS
ISSN1756-5901
Volume4Issue:3
AbstractThe enrichment of transition metals in the brain and the dyshomeostasis of metals are thought to be important etiological factors for elderly people in a number of neurodegenerative diseases, including Alzheimer's disease (AD). However, the understanding of how biometals dynamically dysregulate in the stages of AD development, such as the exact time-dependent and site-dependent accumulation in the brain with AD progression, is still limited. Herein, by using the APP/V717I transgenic mouse model and age-matched mice as control, we offer distinctive in situ and quantitative images of metals (Cu, Fe, Zn and Ca) in brain sections by synchrotron radiation micro beam X-ray fluorescence (SR-mu XRF). The images show that Fe and Ca increased with brain aging in both AD and control (CNT) mice, and Cu, Fe, Zn and Ca appeared significantly elevated in AD mice and showed an obvious age-dependent rise. Fe, Cu and Zn were obviously specifically enriched in the cortex and hippocampus, which were also the plaque-formation sensitive brain regions. Our results demonstrate that the enrichment of transition metals with age and metals' dyshomeostasis in specific regions may contribute together to the etiology and development of AD in elderly people. The XANES measurements of Cu and Fe show evidence that Cu may have redox properties in the AD brain.
Language英语
Funding Project应物所项目组
WOS IDWOS:000300886700008
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13318
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wang, HJ,Wang, M,Wang, B,et al. The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease[J]. METALLOMICS,2012,4(3).
APA Wang, HJ.,Wang, M.,Wang, B.,Li, M.,Chen, HQ.,...&Chai, ZF.(2012).The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease.METALLOMICS,4(3).
MLA Wang, HJ,et al."The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease".METALLOMICS 4.3(2012).
Files in This Item: Download All
File Name/Size DocType Version Access License
The distribution pro(3664KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, HJ]'s Articles
[Wang, M]'s Articles
[Wang, B]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, HJ]'s Articles
[Wang, M]'s Articles
[Wang, B]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, HJ]'s Articles
[Wang, M]'s Articles
[Wang, B]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: The distribution profile and oxidation states of biometals in APP transgenic mouse brain-dyshomeostasis with age and as a function of the development of Alzheimer's disease.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.