CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord
Hu, JZ; Wu, TD; Zeng, L; Liu, HQ(刘慧强); He, Y; Du, GH(杜国浩); Lu, HB
2012
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
ISSN0031-9155
Volume57Issue:5
AbstractComputed tomography combined with angiography has recently been developed to visualize three-dimensional (3D) vascular structure in experimental and clinical studies. However, there remain difficulties in using conventional x-ray angiography to detect small vessels with a diameter less than 200 mu m. This study attempted to develop a novel method for visualizing the micro-angioarchitecture of rat spinal cord. Herein, synchrotron radiation-based x-ray in-line phase contrast computed tomography (IL-XPCT) was used to obtain 3D micro-vessel structure without angiography. The digital phase contrast images were compared with conventional histological sections. Our results clearly demonstrated that the resolution limit of the spatial blood supply network in the normal rat thoracic cord appeared to be as small as similar to 10 mu m. The rendered images were consistent with that obtained from histomorphology sections. In summary, IL-XPCT is a potential tool to investigate the 3D neurovascular morphology of the rat spinal cord without the use of contrast agents, and it could help to evaluate the validity of the pro-or anti-angiogenesis therapeutic strategies on microvasculature repair or regeneration.
Language英语
Funding Project应物所项目组
WOS IDWOS:000300775600003
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13340
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Hu, JZ,Wu, TD,Zeng, L,et al. Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord[J]. PHYSICS IN MEDICINE AND BIOLOGY,2012,57(5).
APA Hu, JZ.,Wu, TD.,Zeng, L.,Liu, HQ.,He, Y.,...&Lu, HB.(2012).Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord.PHYSICS IN MEDICINE AND BIOLOGY,57(5).
MLA Hu, JZ,et al."Visualization of microvasculature by x-ray in-line phase contrast imaging in rat spinal cord".PHYSICS IN MEDICINE AND BIOLOGY 57.5(2012).
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