CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Wollastonite nanofiber-doped self-setting calcium phosphate bioactive cement for bone tissue regeneration
Guo, H(郭瀚); Wei, J; Song, WH; Zhang, S; Yan, YG; Liu, CS; Xiao, TQ(肖体乔)
2012
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume7
AbstractThe purpose of this study was to synthesize a self-setting bioactive cement by incorporation of wollastonite nanofibers (WNFs) into calcium phosphate cement (CPC). The composition, morphology, setting time, compressive strength, hydrophilicity, and degradation of WNF-doped CPC (wnf-CPC) were investigated. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and inductively coupled plasma atomic emission spectroscopy were utilized. Additionally, methyl-thiazolyl-tetrazolium bromide assay, scanning electron microscopy, inductively coupled plasma atomic emission spectroscopy, and histological evaluation were used to study the cell and tissue responses to wnf-CPC, both in vitro and in vivo. The results confirmed that the addition of WNFs into CPC had no obvious effect on the setting time or the compressive strength of wnf-CPC, provided the WNF amount was not more than 10 wt%. However, the hydrophilicity and degradability of wnf-CPC were significantly improved by the addition of WNFs - this was because of the change of microstructure caused by the WNFs. The preferred dissolution of WNFs caused the formation of microporosity in wnf-CPC when soaked in tris hydrochloride solution. The microporosity enlarged the surface area of the wnf-CPC and so promoted degradation of the wnf-CPC when in contact with liquid. In addition, MG-63 cell attachment and proliferation on the wnf-CPC were superior to that on the CPC, indicating that incorporation of WNFs into CPC improved the biological properties for wnf-CPC. Following the implantation of wnf-CPC into bone defects of rabbits, histological evaluation showed that wnf-CPC enhanced the efficiency of new bone formation in comparison with CPC, indicating excellent biocompatibility and osteogenesis of wnf-CPC. In conclusion, wnf-CPC exhibited promising prospects in bone regeneration.
Language英语
Funding Project应物所项目组
WOS IDWOS:000306269900001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13343
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Guo, H,Wei, J,Song, WH,et al. Wollastonite nanofiber-doped self-setting calcium phosphate bioactive cement for bone tissue regeneration[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2012,7.
APA Guo, H.,Wei, J.,Song, WH.,Zhang, S.,Yan, YG.,...&Xiao, TQ.(2012).Wollastonite nanofiber-doped self-setting calcium phosphate bioactive cement for bone tissue regeneration.INTERNATIONAL JOURNAL OF NANOMEDICINE,7.
MLA Guo, H,et al."Wollastonite nanofiber-doped self-setting calcium phosphate bioactive cement for bone tissue regeneration".INTERNATIONAL JOURNAL OF NANOMEDICINE 7(2012).
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