CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Controlled Assembly of Gold Nanoparticles through Antibody Recognition: Study and Utilizing the Effect of Particle Size on Interparticle Distance
Zhou, Guohua; Liu, Yizhen; Luo, Ming; Li, Xiuhong; Xu, Qinfeng; Ji, Xinghu; He, Zhike
2013
Source PublicationLANGMUIR
Pages4697
Conference Date2013
AbstractAn assembly of gold nanoparticle through the recognition of unmodified antibody was developed. The use of peptide (Cys-Ala-Leu-Asn-Asn) as ligands to stabilize and functionalize gold nanoparticles provides technical and operational convenience. These peptide-capped particles in different sizes are recognized by antibody and assembly to form dimers and expanded hybrid material by controlling the conditions. The interparticle spacing of these assemblies was well studied with small-angle X-ray scattering measurements, and it was found that the interparticle spacing is inversely dependent on the particle size. This relationship of interparticle spacing and particle size is closely related to the structure of antibody linker. Therefore, analyzing the interparticle spacing of assemblies can reveal the equilibrium configuration of IgG. Based on the investigation, the Fab-Fab angle of IgG is obtained to be approximate to 102 degrees and the Fab arms are approximate to 7.8 nm. These results provide new experimental data on the structure of flexible IgG.
ISSN0743-7463
Indexed BySCI
Funding Project应物所课题组
Language英语
WOS IDWOS:000317813300007
Citation statistics
Document Type会议论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13588
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Zhou, Guohua,Liu, Yizhen,Luo, Ming,et al. Controlled Assembly of Gold Nanoparticles through Antibody Recognition: Study and Utilizing the Effect of Particle Size on Interparticle Distance[C],2013:4697.
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