CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers
Ren, Wenzhi; Zeng, Leyong; Shen, Zheyu; Xiang, Lingchao; Gong, An; Zhang, Jichao(张继超); Mao, Chengwen; Li, Aiguo(李爱国); Paunesku, Tatjana; Woloschak, Gayle E.; Hosmane, Narayan S.; Wu, Aiguo
2013
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume3Issue:43Pages:CONCATENATE(Sheet1!I116,-Sheet1!J116)
AbstractIn order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000325950600167
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13613
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Ren, Wenzhi,Zeng, Leyong,Shen, Zheyu,et al. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers[J]. RSC ADVANCES,2013,3(43):CONCATENATE(Sheet1!I116,-Sheet1!J116).
APA Ren, Wenzhi.,Zeng, Leyong.,Shen, Zheyu.,Xiang, Lingchao.,Gong, An.,...&Wu, Aiguo.(2013).Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers.RSC ADVANCES,3(43),CONCATENATE(Sheet1!I116,-Sheet1!J116).
MLA Ren, Wenzhi,et al."Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers".RSC ADVANCES 3.43(2013):CONCATENATE(Sheet1!I116,-Sheet1!J116).
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