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| Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers | |
| Ren, Wenzhi; Zeng, Leyong; Shen, Zheyu; Xiang, Lingchao; Gong, An; Zhang, Jichao（张继超）; Mao, Chengwen; Li, Aiguo（李爱国）; Paunesku, Tatjana; Woloschak, Gayle E.; Hosmane, Narayan S.; Wu, Aiguo | |
| 2013 | |
| Source Publication | RSC ADVANCES
 |
| ISSN | 2046-2069 |
| Volume | 3Issue:43Pages:CONCATENATE(Sheet1!I116,-Sheet1!J116) |
| Abstract | In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000325950600167 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13613 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Ren, Wenzhi,Zeng, Leyong,Shen, Zheyu,et al. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers[J]. RSC ADVANCES,2013,3(43):CONCATENATE(Sheet1!I116,-Sheet1!J116). |
| APA | Ren, Wenzhi.,Zeng, Leyong.,Shen, Zheyu.,Xiang, Lingchao.,Gong, An.,...&Wu, Aiguo.(2013).Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers.RSC ADVANCES,3(43),CONCATENATE(Sheet1!I116,-Sheet1!J116). |
| MLA | Ren, Wenzhi,et al."Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers".RSC ADVANCES 3.43(2013):CONCATENATE(Sheet1!I116,-Sheet1!J116). |
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| Enhanced doxorubicin（780KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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