CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
F-18 Labeled Vasoactive Intestinal Peptide Analogue in the PET Imaging of Colon Carcinoma in Nude Mice
Cheng, Dengfeng; Liu, Yuxia; Shen, Hua; Pang, Lifang; Yin, Duanzhi(尹端沚); Wang, Yongxian(汪勇先); Li, Shanqun; Shi, Hongcheng
2013
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133; 2314-6141
AbstractAs large amount of vasoactive intestinal peptide (VIP) receptors are expressed in various tumors and VIP-related diseases, radiolabeled VIP provides a potential PET imaging agent for VIP receptor. However, structural modification of VIP is required before being radiolabeled and used for VIP receptor imaging due to its poor in vivo stability. As a VIP analogue, [R-8,R-15,R-21, L-17]-VIP exhibited improved stability and receptor specificity in preliminary studies. In this study, F-18 labeled [R-8,R-15,R-21, L-17]-VIP was produced with the radiochemical yield being as high as 33.6% +/- 3% (decay-for-corrected, n = 5) achieved within 100 min, a specific activity of 255 GBq/mu mol, and a radiochemical purity as high as 99% as characterized by radioactive HPLC, TLC, and SDS-Page radioautography. A biodistribution study in normal mice also demonstrated fast elimination of F-18 labeled [R-8,R-15,R-21, L-17]-VIP in the blood, liver, and gastrointestinal tracts. A further micro-PET imaging study in C26 colon carcinoma bearing mice confirmed the high tumor specificity, with the tumor/muscle radioactivity uptake ratio being as high as 3.03 at 60 min following injection, and no apparent radioactivity concentration in the intestinal tracts. In addition, blocking experiment and Western Blot test further confirmed its potential in PET imaging of VIP receptor-positive tumor.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000329650400001
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13615
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Cheng, Dengfeng,Liu, Yuxia,Shen, Hua,et al. F-18 Labeled Vasoactive Intestinal Peptide Analogue in the PET Imaging of Colon Carcinoma in Nude Mice[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Cheng, Dengfeng.,Liu, Yuxia.,Shen, Hua.,Pang, Lifang.,Yin, Duanzhi.,...&Shi, Hongcheng.(2013).F-18 Labeled Vasoactive Intestinal Peptide Analogue in the PET Imaging of Colon Carcinoma in Nude Mice.BIOMED RESEARCH INTERNATIONAL.
MLA Cheng, Dengfeng,et al."F-18 Labeled Vasoactive Intestinal Peptide Analogue in the PET Imaging of Colon Carcinoma in Nude Mice".BIOMED RESEARCH INTERNATIONAL (2013).
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