CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Hierarchical ordering of amyloid fibrils on the mica surface
Zhou, Xingfei; Zhang, Yingying; Zhang, Feng; Pillai, Saju; Liu, Jianhua; Li, Rong; Dai, Bin; Li, Bin(李宾); Zhang, Yi(张益)
2013
Source PublicationNANOSCALE
ISSN2040-3364
Volume5Issue:11Pages:CONCATENATE(Sheet1!I145,-Sheet1!J145)
AbstractThe aggregation of amyloid peptides into ordered fibrils is closely associated with many neuro-degenerative diseases. The surfaces of cell membranes and biomolecules are believed to play important roles in modulation of peptide aggregation under physiological conditions. Experimental studies of fibrillogenesis at the molecular level in vivo, however, are inherently challenging, and the molecular mechanisms of how surface affects the structure and ordering of amyloid fibrils still remain elusive. Herein we have investigated the aggregation behavior of insulin peptides within water films adsorbed on the mica surface. AFM measurements revealed that the structure and orientation of fibrils were significantly affected by the mica lattice and the peptide concentration. At low peptide concentration (similar to 0.05 mg mL(-1)), there appeared a single layer of short and well oriented fibrils with a mean height of 1.6 nm. With an increase of concentration to a range of 0.2-2.0 mg mL(-1), a different type of fibrils with a mean height of 3.8 nm was present. Interestingly, when the concentration was above 2.0 mg mL(-1), the thicker fibrils exhibited two-dimensional liquid-crystal-like ordering probably caused by the combination of entropic and electrostatic forces. These results could help us gain better insight into the effects of the substrate on amyloid fibrillation.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000319008700033
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13619
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhou, Xingfei,Zhang, Yingying,Zhang, Feng,et al. Hierarchical ordering of amyloid fibrils on the mica surface[J]. NANOSCALE,2013,5(11):CONCATENATE(Sheet1!I145,-Sheet1!J145).
APA Zhou, Xingfei.,Zhang, Yingying.,Zhang, Feng.,Pillai, Saju.,Liu, Jianhua.,...&Zhang, Yi.(2013).Hierarchical ordering of amyloid fibrils on the mica surface.NANOSCALE,5(11),CONCATENATE(Sheet1!I145,-Sheet1!J145).
MLA Zhou, Xingfei,et al."Hierarchical ordering of amyloid fibrils on the mica surface".NANOSCALE 5.11(2013):CONCATENATE(Sheet1!I145,-Sheet1!J145).
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