Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility | |
| Li, Rong; Wang, Hengdong; Wang, Wenfeng; Ye, Yin | |
| 2013 | |
| Source Publication | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
 |
| ISSN | 0920-5063 |
| Volume | 24Issue:1Pages:CONCATENATE(Sheet1!I162,-Sheet1!J162) |
| Abstract | A polypropylene non-woven fabric (PPNWF) was exposed to oxygen plasma to produce peroxides on its surface. These peroxides were used to initiate graft polymerization of acrylic acid (AA) on the surface of PPNWF. Direct heparinization was accomplished via a reaction between heparin and PP-PAA (AA grafted PPNWF) which was activated by EDC (N-ethyl-N'-[3-(dimethylamino)propyl] carbodiimide). Indirect heparinized PPNWF was prepared by grafting poly(ethylene oxide) (PEO) on a PP-PAA surface to form PP-PAA-PEO, followed by reaction with heparin which was activated by EDC before use. The surface-modified PPNWFs were characterized by attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopy, electron spectroscopy for chemical analysis (ESCA) and contact angle goniometry. It was found that hydrophilicity was greatly improved, as indicated by the decrease of the water contact angle from 142 to 33 degrees. In vitro blood compatibility evaluation of modified PPNWFs, including hemolysis rate, platelet adhesion, plasma protein adsorption and activated partial thromboplastin time (APTT) was investigated. The results suggested that both heparinized PPNWFs showed lower hemolysis rates and better platelet anti-adhesion than non-heparinized controls. Furthermore, PPNWF obtained via indirect immobilization of heparin showed better hydrophilicity and blood compatibility than direct heparinization of PPNWF. (C) Koninklijke Brill NV, Leiden, 2012 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000311543500002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13625 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Li, Rong,Wang, Hengdong,Wang, Wenfeng,et al. Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2013,24(1):CONCATENATE(Sheet1!I162,-Sheet1!J162). |
| APA | Li, Rong,Wang, Hengdong,Wang, Wenfeng,&Ye, Yin.(2013).Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,24(1),CONCATENATE(Sheet1!I162,-Sheet1!J162). |
| MLA | Li, Rong,et al."Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 24.1(2013):CONCATENATE(Sheet1!I162,-Sheet1!J162). |
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| Immobilization of He（849KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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