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Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility
Li, Rong; Wang, Hengdong; Wang, Wenfeng; Ye, Yin
2013
Source PublicationJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
ISSN0920-5063
Volume24Issue:1Pages:CONCATENATE(Sheet1!I162,-Sheet1!J162)
AbstractA polypropylene non-woven fabric (PPNWF) was exposed to oxygen plasma to produce peroxides on its surface. These peroxides were used to initiate graft polymerization of acrylic acid (AA) on the surface of PPNWF. Direct heparinization was accomplished via a reaction between heparin and PP-PAA (AA grafted PPNWF) which was activated by EDC (N-ethyl-N'-[3-(dimethylamino)propyl] carbodiimide). Indirect heparinized PPNWF was prepared by grafting poly(ethylene oxide) (PEO) on a PP-PAA surface to form PP-PAA-PEO, followed by reaction with heparin which was activated by EDC before use. The surface-modified PPNWFs were characterized by attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopy, electron spectroscopy for chemical analysis (ESCA) and contact angle goniometry. It was found that hydrophilicity was greatly improved, as indicated by the decrease of the water contact angle from 142 to 33 degrees. In vitro blood compatibility evaluation of modified PPNWFs, including hemolysis rate, platelet adhesion, plasma protein adsorption and activated partial thromboplastin time (APTT) was investigated. The results suggested that both heparinized PPNWFs showed lower hemolysis rates and better platelet anti-adhesion than non-heparinized controls. Furthermore, PPNWF obtained via indirect immobilization of heparin showed better hydrophilicity and blood compatibility than direct heparinization of PPNWF. (C) Koninklijke Brill NV, Leiden, 2012
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000311543500002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13625
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, Rong,Wang, Hengdong,Wang, Wenfeng,et al. Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2013,24(1):CONCATENATE(Sheet1!I162,-Sheet1!J162).
APA Li, Rong,Wang, Hengdong,Wang, Wenfeng,&Ye, Yin.(2013).Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,24(1),CONCATENATE(Sheet1!I162,-Sheet1!J162).
MLA Li, Rong,et al."Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 24.1(2013):CONCATENATE(Sheet1!I162,-Sheet1!J162).
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