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Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T-2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells
Zeng, Leyong; Xiang, Lingchao; Ren, Wenzhi; Zheng, Jianjun; Li, Tianhua; Chen, Bin; Zhang, Jichao; Mao, Chengwen; Li, Aiguo; Wu, Aiguo
2013
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume3Issue:33Pages:CONCATENATE(Sheet1!I221,-Sheet1!J221)
AbstractDue to non-invasive deep imaging and therapy, multifunctional agents of magnetic resonance (MR)/upconversion luminescence (UCL) imaging and photodynamic therapy (PDT) play an important role in clinical diagnosis and treatment of cancers, and also in the assessment of therapy effect. In this paper, tetra-sulfonic phthalocyanine aluminium (AlPcS4) photosensitizers-conjugated Fe3O4@NaYF4:Yb/Er (NPs-AlPcS4) nanocomplexes were synthesized for the T-2-weighted MR/UCL imaging and PDT of cancer cells. The PEG-coated Fe3O4@ NaYF4:Yb/Er nanoparticles (NPs) with a core-shell structure showed strong T-2-weighted MR relaxivity (r(2) = 42.131 mM(-1) s(-1)) and UCL emission in the visible region (the bands at about 654-674 nm, 545 nm and 524 nm), and were conjugated successfully with AlPcS4 photosensitizer by electrostatic interaction. By direct observation of XFM and staining with Prussian blue, the element distribution and location of NPs in MCF-7 cells were characterized, respectively. Under irradiation from a 980 nm laser, the death ratio of MCF-7 cells incubated with NPs-AlPcS4 nanocomplexes could be up to about 70%. The results indicated that the as-prepared NPs-AlPcS4 nanocomplexes would be a potential candidate as multifunctional nanoprobes for the dual-modal T-2-weighted MR/UCL imaging and PDT of cancers in the future.
Indexed BySCI
Funding Project应物所项目组
WOS IDWOS:000322464500051
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13631
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zeng, Leyong,Xiang, Lingchao,Ren, Wenzhi,et al. Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T-2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells[J]. RSC ADVANCES,2013,3(33):CONCATENATE(Sheet1!I221,-Sheet1!J221).
APA Zeng, Leyong.,Xiang, Lingchao.,Ren, Wenzhi.,Zheng, Jianjun.,Li, Tianhua.,...&Wu, Aiguo.(2013).Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T-2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells.RSC ADVANCES,3(33),CONCATENATE(Sheet1!I221,-Sheet1!J221).
MLA Zeng, Leyong,et al."Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T-2-weighted magnetic resonance/upconversion luminescence imaging and photodynamic therapy of cancer cells".RSC ADVANCES 3.33(2013):CONCATENATE(Sheet1!I221,-Sheet1!J221).
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