CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Synchrotron radiation X-ray fluorescence analysis of biodistribution and pulmonary toxicity of nanoscale titanium dioxide in mice
Zhang, Jichao; Li, Bo; Zhang, Yi; Li, Aiguo; Yu, Xiaohan; Huang, Qing; Fana, Chunhai; Cai, Xiaoqing
2013
Source PublicationANALYST
ISSN0003-2654
Volume138Issue:21Pages:CONCATENATE(Sheet1!I346,-Sheet1!J346)
AbstractUsing synchrotron radiation X-ray fluorescence (SRXRF), we have examined the biodistribution and pulmonary toxicity of nanoscale titanium dioxide (nanoTiO(2)) in mice at the elemental level. Notably, nanoTiO(2) particles were mainly retained in lungs after intratracheal instillation, slowly cleared and were still present at 3 months. Different methods of intratracheal instillation influenced the clearance of nanoTiO(2) from lungs. NanoTiO(2) interfered with the natural distribution of K, Ca, Fe, Cu and Zn in lungs. We have thus demonstrated that SRXRF provides an effective approach to investigate the distribution of metal nanomaterials and native metal elements in tissues and organs, which offers new opportunities for revealing nanotoxic mechanisms of nanomaterials.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000325366700042
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13641
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhang, Jichao,Li, Bo,Zhang, Yi,et al. Synchrotron radiation X-ray fluorescence analysis of biodistribution and pulmonary toxicity of nanoscale titanium dioxide in mice[J]. ANALYST,2013,138(21):CONCATENATE(Sheet1!I346,-Sheet1!J346).
APA Zhang, Jichao.,Li, Bo.,Zhang, Yi.,Li, Aiguo.,Yu, Xiaohan.,...&Cai, Xiaoqing.(2013).Synchrotron radiation X-ray fluorescence analysis of biodistribution and pulmonary toxicity of nanoscale titanium dioxide in mice.ANALYST,138(21),CONCATENATE(Sheet1!I346,-Sheet1!J346).
MLA Zhang, Jichao,et al."Synchrotron radiation X-ray fluorescence analysis of biodistribution and pulmonary toxicity of nanoscale titanium dioxide in mice".ANALYST 138.21(2013):CONCATENATE(Sheet1!I346,-Sheet1!J346).
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