CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Aggregated Gas Molecules: Toxic to Protein?
Zhang, Meng; Zuo, Guanghong; Chen, Jixiu; Gao, Yi; Fang, Haiping(方海平)
AbstractThe biological toxicity of high levels of breathing gases has been known for centuries, but the mechanism remains elusive. Earlier work mainly focused on the influences of dispersed gas molecules dissolved in water on biomolecules. However, recent studies confirmed the existence of aggregated gas molecules at the water-solid interface. In this paper, we have investigated the binding preference of aggregated gas molecules on proteins with molecular dynamics simulations, using nitrogen (N-2) gas and the Src-homology 3 (SH3) domain as the model system. Aggregated N-2 molecules were strongly bound by the active sites of the SH3 domain, which could impair the activity of the protein. In contrast, dispersed N2 molecules did not specifically interact with the SH3 domain. These observations extend our understanding of the possible toxicity of aggregates of gas molecules in the function of proteins.
Indexed BySCI
Funding Project应物所项目组
WOS IDWOS:000317576800001
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Zhang, Meng,Zuo, Guanghong,Chen, Jixiu,et al. Aggregated Gas Molecules: Toxic to Protein?[J]. SCIENTIFIC REPORTS,2013,3.
APA Zhang, Meng,Zuo, Guanghong,Chen, Jixiu,Gao, Yi,&Fang, Haiping.(2013).Aggregated Gas Molecules: Toxic to Protein?.SCIENTIFIC REPORTS,3.
MLA Zhang, Meng,et al."Aggregated Gas Molecules: Toxic to Protein?".SCIENTIFIC REPORTS 3(2013).
Files in This Item: Download All
File Name/Size DocType Version Access License
Aggregated Gas Molec(1488KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Meng]'s Articles
[Zuo, Guanghong]'s Articles
[Chen, Jixiu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Meng]'s Articles
[Zuo, Guanghong]'s Articles
[Chen, Jixiu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Meng]'s Articles
[Zuo, Guanghong]'s Articles
[Chen, Jixiu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Aggregated Gas Molecules-Toxic to Protein.pdf
Format: Adobe PDF
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.