CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Antibody i-Patch prediction of the antibody binding site improves rigid local antibodyantigen docking
Krawczyk, Konrad; Baker, Terry; Shi, Jiye; Deane, Charlotte M.
2013
Source PublicationPROTEIN ENGINEERING DESIGN & SELECTION
ISSN1741-0126
Volume26Issue:10Pages:CONCATENATE(Sheet1!I33,-Sheet1!J33)
AbstractAntibodies are a class of proteins indispensable for the vertebrate immune system. The general architecture of all antibodies is very similar, but they contain a hypervariable region which allows millions of antibody variants to exist, each of which can bind to different molecules. This binding malleability means that antibodies are an increasingly important category of biopharmaceuticals and biomarkers. We present Antibody i-Patch, a method that annotates the most likely antibody residues to be in contact with the antigen. We show that our predictions correlate with energetic importance and thus we argue that they may be useful in guiding mutations in the artificial affinity maturation process. Using our predictions as constraints for a rigid-body docking algorithm, we are able to obtain high-quality results in minutes. Our annotation method and re-scoring system for docking achieve their predictive power by using antibody-specific statistics. Antibody i-Patch is available from http://www.stats.ox.ac.uk/research/proteins/resources.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000325185400008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13671
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Krawczyk, Konrad,Baker, Terry,Shi, Jiye,et al. Antibody i-Patch prediction of the antibody binding site improves rigid local antibodyantigen docking[J]. PROTEIN ENGINEERING DESIGN & SELECTION,2013,26(10):CONCATENATE(Sheet1!I33,-Sheet1!J33).
APA Krawczyk, Konrad,Baker, Terry,Shi, Jiye,&Deane, Charlotte M..(2013).Antibody i-Patch prediction of the antibody binding site improves rigid local antibodyantigen docking.PROTEIN ENGINEERING DESIGN & SELECTION,26(10),CONCATENATE(Sheet1!I33,-Sheet1!J33).
MLA Krawczyk, Konrad,et al."Antibody i-Patch prediction of the antibody binding site improves rigid local antibodyantigen docking".PROTEIN ENGINEERING DESIGN & SELECTION 26.10(2013):CONCATENATE(Sheet1!I33,-Sheet1!J33).
Files in This Item: Download All
File Name/Size DocType Version Access License
Antibody i-Patch pre(454KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Krawczyk, Konrad]'s Articles
[Baker, Terry]'s Articles
[Shi, Jiye]'s Articles
Baidu academic
Similar articles in Baidu academic
[Krawczyk, Konrad]'s Articles
[Baker, Terry]'s Articles
[Shi, Jiye]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Krawczyk, Konrad]'s Articles
[Baker, Terry]'s Articles
[Shi, Jiye]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Antibody i-Patch prediction of the antibody binding site improves rigid local antibodyantigen docking.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.