CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice
Li, Bo; Yang, Jianzhong(杨建忠); Huang, Qing(黄庆); Zhang, Yi; Peng, Cheng(彭程); Zhang, Yujie; He, Yao; Shi, Jiye; Li, Wenxin(李文新); Hu, Jun(胡钧); Fan, Chunhai(樊春海)
2013
Source PublicationNPG ASIA MATERIALS
ISSN1884-4049
Volume5
AbstractGraphene and its derivatives (for example, nanoscale graphene oxide (NGO)) have emerged as extremely attractive nanomaterials for a wide range of applications, including diagnostics and therapeutics. In this work, we present a systematic study on the in vivo distribution and pulmonary toxicity of NGO for up to 3 months after exposure. Radioisotope tracing and morphological observation demonstrated that intratracheally instilled NGO was mainly retained in the lung. NGO could result in acute lung injury (ALI) and chronic pulmonary fibrosis. Such NGO-induced ALI was related to oxidative stress and could effectively be relieved with dexamethasone treatment. In addition, we found that the biodistribution of I-125-NGO varied greatly from that of I-125 ions, hence it is possible that nanoparticulates could deliver radioactive isotopes deep into the lung, which might settle in numerous 'hot spots' that could result in mutations and cancers, raising environmental concerns about the large-scale production of graphene oxide. NPG Asia Materials (2013) 5, e44; doi:10.1038/am.2013.7; published online 5 April 2013
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000318147400001
Citation statistics
Cited Times:78[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13681
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, Bo,Yang, Jianzhong,Huang, Qing,et al. Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice[J]. NPG ASIA MATERIALS,2013,5.
APA Li, Bo.,Yang, Jianzhong.,Huang, Qing.,Zhang, Yi.,Peng, Cheng.,...&Fan, Chunhai.(2013).Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice.NPG ASIA MATERIALS,5.
MLA Li, Bo,et al."Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice".NPG ASIA MATERIALS 5(2013).
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