CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis
Zhang, Yi(张益); Wang, Lu; Sun, Yanhong(孙艳红); Zhu, Ying(诸颖); Zhong, Zengtao; Shi, Jiye; Fan, Chunhai(樊春海); Huang, Qing(黄庆)
2013
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume5Issue:11Pages:CONCATENATE(Sheet1!I64,-Sheet1!J64)
AbstractDexamethasone (DEX) is a well-known anti-inflammatory drug, whose widespread clinical use is nevertheless restricted by its serious side effects. By conjugation of DEX with C-60, we found that this nanomedicine retained the anti-inflammatory activity of DEX while reducing side effects in the animal model. In mouse thymocytes, the CCK-8 assay showed that the cytotoxicity of DEX-C-60 was significantly lower than that of free DEX. Flow cytometric studies revealed that incubation with DEX-C-60 induced much less apoptotic thymocytes. Interestingly, such reduced cytotoxicity and apoptosis were not observed when equal moles of free C-60 and free DEX were coincubated with thymocytes suggesting that the conjugation alters the signal pathway of DEX Indeed, found that the binding of DEX-C-60 and a glucocorticoid receptor (GR) was partially blocked in the thymocytes, which resulted in down-regulation of several apoptosis-related genes. These findings help understand the mechanism of beneficial effects of this new nanomedicine, DEX-C-60, and promote its clinical applications.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000320484000107
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13696
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhang, Yi,Wang, Lu,Sun, Yanhong,et al. Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(11):CONCATENATE(Sheet1!I64,-Sheet1!J64).
APA Zhang, Yi.,Wang, Lu.,Sun, Yanhong.,Zhu, Ying.,Zhong, Zengtao.,...&Huang, Qing.(2013).Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis.ACS APPLIED MATERIALS & INTERFACES,5(11),CONCATENATE(Sheet1!I64,-Sheet1!J64).
MLA Zhang, Yi,et al."Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis".ACS APPLIED MATERIALS & INTERFACES 5.11(2013):CONCATENATE(Sheet1!I64,-Sheet1!J64).
Files in This Item: Download All
File Name/Size DocType Version Access License
Conjugation of Dexam(2576KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Yi(张益)]'s Articles
[Wang, Lu]'s Articles
[Sun, Yanhong(孙艳红)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Yi(张益)]'s Articles
[Wang, Lu]'s Articles
[Sun, Yanhong(孙艳红)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Yi(张益)]'s Articles
[Wang, Lu]'s Articles
[Sun, Yanhong(孙艳红)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Conjugation of Dexamethasone to C60 for the Design of an Anti-Inflammatory Nanomedicine with Reduced Cellular Apoptosis.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.