CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets
Tu, Yusong; Lv, Min(吕敏); Xiu, Peng; Huynh, Tien; Zhang, Meng; Castelli, Matteo; Liu, Zengrong; Huang, Qing(黄庆); Fan, Chunhai(樊春海); Fang, Haiping(方海平); Zhou, Ruhong
2013
Source PublicationNATURE NANOTECHNOLOGY
ISSN1748-3387
Volume8Issue:8Pages:CONCATENATE(Sheet1!I78,-Sheet1!J78)
AbstractUnderstanding how nanomaterials interact with cell membranes is related to how they cause cytotoxicity and is therefore critical for designing safer biomedical applications. Recently, graphene (a two-dimensional nanomaterial) was shown to have antibacterial activity on Escherichia coli, but its underlying molecular mechanisms remain unknown. Here we show experimentally and theoretically that pristine graphene and graphene oxide nanosheets can induce the degradation of the inner and outer cell membranes of Escherichia coli, and reduce their viability. Transmission electron microscopy shows three rough stages, and molecular dynamics simulations reveal the atomic details of the process. Graphene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes because of the strong dispersion interactions between graphene and lipid molecules. This destructive extraction offers a novel mechanism for the molecular basis of graphene's cytotoxicity and antibacterial activity.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000322713500016
Citation statistics
Cited Times:601[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13708
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Tu, Yusong,Lv, Min,Xiu, Peng,et al. Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets[J]. NATURE NANOTECHNOLOGY,2013,8(8):CONCATENATE(Sheet1!I78,-Sheet1!J78).
APA Tu, Yusong.,Lv, Min.,Xiu, Peng.,Huynh, Tien.,Zhang, Meng.,...&Zhou, Ruhong.(2013).Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets.NATURE NANOTECHNOLOGY,8(8),CONCATENATE(Sheet1!I78,-Sheet1!J78).
MLA Tu, Yusong,et al."Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets".NATURE NANOTECHNOLOGY 8.8(2013):CONCATENATE(Sheet1!I78,-Sheet1!J78).
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