Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons | |
| Cao, Yanhua; Liu, Huajie; Li, Qingzhao; Wang, Qian; Zhang, Wenli; Chen, Yinping; Wang, Dong; Cai, Yuan | |
| 2013 | |
| Source Publication | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| ISSN | 0162-0134 |
| Volume | 126Pages:CONCATENATE(Sheet1!I98,-Sheet1!J98) |
| Abstract | PbS nanoparticles (NPs) is an important nanomaterial for biomedical imaging in living tissues. However, concerning the high toxicity, especially neurotoxicity, of Pb element, it is crucial that the toxicity assessment of "naked" PbS NPs should be adequately studied. In the current study, we systematically explored the neurotoxicity of PbS NPs in rats by measuring the body weight and brain coefficient changes, testing memory behaviors in Y-electric maze, and studying the neuronal ultrastructure and pathology in hippocampus. Furthermore, in order to study the toxic mechanism, we performed Pb and Ca content measurements in various organs, and investigated Ca2+-ATPase activity and L-type calcium channel subunit expression. Our results confirmed that PbS NPs showed high neurotoxicity, while a possible mechanism was suggested to be due to the PbS NPs-induced calcium homeostasis disorder which was caused by the abnormal calcium transportation. (C) 2013 Elsevier Inc. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000322942400010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13727 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Cao, Yanhua,Liu, Huajie,Li, Qingzhao,et al. Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2013,126:CONCATENATE(Sheet1!I98,-Sheet1!J98). |
| APA | Cao, Yanhua.,Liu, Huajie.,Li, Qingzhao.,Wang, Qian.,Zhang, Wenli.,...&Cai, Yuan.(2013).Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons.JOURNAL OF INORGANIC BIOCHEMISTRY,126,CONCATENATE(Sheet1!I98,-Sheet1!J98). |
| MLA | Cao, Yanhua,et al."Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons".JOURNAL OF INORGANIC BIOCHEMISTRY 126(2013):CONCATENATE(Sheet1!I98,-Sheet1!J98). |
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| File Name/Size | DocType | Version | Access | License | ||
| Effect of lead sulfi（1493KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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