CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons
Cao, Yanhua; Liu, Huajie; Li, Qingzhao; Wang, Qian; Zhang, Wenli; Chen, Yinping; Wang, Dong; Cai, Yuan
2013
Source PublicationJOURNAL OF INORGANIC BIOCHEMISTRY
ISSN0162-0134
Volume126Pages:CONCATENATE(Sheet1!I98,-Sheet1!J98)
AbstractPbS nanoparticles (NPs) is an important nanomaterial for biomedical imaging in living tissues. However, concerning the high toxicity, especially neurotoxicity, of Pb element, it is crucial that the toxicity assessment of "naked" PbS NPs should be adequately studied. In the current study, we systematically explored the neurotoxicity of PbS NPs in rats by measuring the body weight and brain coefficient changes, testing memory behaviors in Y-electric maze, and studying the neuronal ultrastructure and pathology in hippocampus. Furthermore, in order to study the toxic mechanism, we performed Pb and Ca content measurements in various organs, and investigated Ca2+-ATPase activity and L-type calcium channel subunit expression. Our results confirmed that PbS NPs showed high neurotoxicity, while a possible mechanism was suggested to be due to the PbS NPs-induced calcium homeostasis disorder which was caused by the abnormal calcium transportation. (C) 2013 Elsevier Inc. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000322942400010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13727
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Cao, Yanhua,Liu, Huajie,Li, Qingzhao,et al. Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2013,126:CONCATENATE(Sheet1!I98,-Sheet1!J98).
APA Cao, Yanhua.,Liu, Huajie.,Li, Qingzhao.,Wang, Qian.,Zhang, Wenli.,...&Cai, Yuan.(2013).Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons.JOURNAL OF INORGANIC BIOCHEMISTRY,126,CONCATENATE(Sheet1!I98,-Sheet1!J98).
MLA Cao, Yanhua,et al."Effect of lead sulfide nanoparticles exposure on calcium homeostasis in rat hippocampus neurons".JOURNAL OF INORGANIC BIOCHEMISTRY 126(2013):CONCATENATE(Sheet1!I98,-Sheet1!J98).
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