Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells | |
| Wang, Lu; Xu, Xiaoping; Zhang, Yi（张益）; Zhang, Yuanqing; Zhu, Ying（诸颖）; Shi, Jiye; Sun, Yanhong（孙艳红）; Huang, Qing（黄庆） | |
| 2013 | |
| Source Publication | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
 |
| ISSN | 0957-4530 |
| Volume | 24Issue:9Pages:CONCATENATE(Sheet1!I112,-Sheet1!J112) |
| Abstract | Curcumin has anti-proliferative and pro-apototic properties against a variety of cancer cells in vitro. Unfortunately, the water-insolubility and instability leads to its low bioavailability in vivo tests. Here, we report a general approach to using poly(amidoamine) dendrimer with acetyl terminal groups to encapsulate curcumin(G(5)-Ac/Cur) for drug delivery to cancer cells. The solubility, release kinetics, anticancer activity, and apoptotic-related protein expression (Bax and Bcl-2) were investigated in detail. Comparing with curcumin, the water-solubility value of G(5)-Ac/Cur increased 200-fold, and the release of curcumin from the complexes was in a sustained manner. G(5)-Ac/Cur showed higher anti-proliferative activity against A549 cell lines and had the better effect on the generation of intracellular reactive oxygen species, the mitochondrial membrane potential and cell apoptosis. Furthermore, the ratio of Bax/Bcl-2 was higher in samples treated with G(5)-Ac/Cur. The results indicated that the G(5)-Ac drug delivery system could improve the solubility and anti-cancer effect of curcumin. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000323289600006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13739 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Wang, Lu,Xu, Xiaoping,Zhang, Yi,et al. Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2013,24(9):CONCATENATE(Sheet1!I112,-Sheet1!J112). |
| APA | Wang, Lu.,Xu, Xiaoping.,Zhang, Yi.,Zhang, Yuanqing.,Zhu, Ying.,...&Huang, Qing.(2013).Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,24(9),CONCATENATE(Sheet1!I112,-Sheet1!J112). |
| MLA | Wang, Lu,et al."Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 24.9(2013):CONCATENATE(Sheet1!I112,-Sheet1!J112). |
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| Encapsulation of cur（516KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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