CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells
Wang, Lu; Xu, Xiaoping; Zhang, Yi(张益); Zhang, Yuanqing; Zhu, Ying(诸颖); Shi, Jiye; Sun, Yanhong(孙艳红); Huang, Qing(黄庆)
2013
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN0957-4530
Volume24Issue:9Pages:CONCATENATE(Sheet1!I112,-Sheet1!J112)
AbstractCurcumin has anti-proliferative and pro-apototic properties against a variety of cancer cells in vitro. Unfortunately, the water-insolubility and instability leads to its low bioavailability in vivo tests. Here, we report a general approach to using poly(amidoamine) dendrimer with acetyl terminal groups to encapsulate curcumin(G(5)-Ac/Cur) for drug delivery to cancer cells. The solubility, release kinetics, anticancer activity, and apoptotic-related protein expression (Bax and Bcl-2) were investigated in detail. Comparing with curcumin, the water-solubility value of G(5)-Ac/Cur increased 200-fold, and the release of curcumin from the complexes was in a sustained manner. G(5)-Ac/Cur showed higher anti-proliferative activity against A549 cell lines and had the better effect on the generation of intracellular reactive oxygen species, the mitochondrial membrane potential and cell apoptosis. Furthermore, the ratio of Bax/Bcl-2 was higher in samples treated with G(5)-Ac/Cur. The results indicated that the G(5)-Ac drug delivery system could improve the solubility and anti-cancer effect of curcumin.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000323289600006
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13739
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Wang, Lu,Xu, Xiaoping,Zhang, Yi,et al. Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2013,24(9):CONCATENATE(Sheet1!I112,-Sheet1!J112).
APA Wang, Lu.,Xu, Xiaoping.,Zhang, Yi.,Zhang, Yuanqing.,Zhu, Ying.,...&Huang, Qing.(2013).Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,24(9),CONCATENATE(Sheet1!I112,-Sheet1!J112).
MLA Wang, Lu,et al."Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 24.9(2013):CONCATENATE(Sheet1!I112,-Sheet1!J112).
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