CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides
Kang, Seung-gu; Tien Huynh; Xia, Zhen; Zhang, Yi(张益); Fang, Haiping(方海平); Wei, Guanghong; Zhou, Ruhong
2013
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume135Issue:8Pages:CONCATENATE(Sheet1!I155,-Sheet1!J155)
AbstractThe molecular mechanism of epitaxial fibril formation has been investigated for GAV-9 (NH3+-VGGAV-VAGV-CONH2), an amyloid-like peptide extracted from a consensus sequence of amyloidogenic proteins, which assembles with very different morphologies, "upright" on mica and "flat" on the highly oriented pyrolytic graphite (HOPG). Our all-atom molecular dynamics simulations reveal that the strong electrostatic interaction induces the "upright" conformation on mica, whereas the hydrophobic interaction favors the "flat" conformation on HOPG. We also show that the epitaxial pattern on mica is ensured by the lattice matching between the anisotropic binding sites of the basal substrate and the molecular dimension of GAV-9, accompanied with a long-range order of well-defined beta-strands. Furthermore, the binding free energy surfaces indicate that the longitudinal assembly growth is predominantly driven by the hydrophobic interaction along the longer crystallographic unit cell direction of mica. These findings provide a molecular basis for the surface-assisted molecular assembly, which might also be useful for the design of de novo nanodevices.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000315618900048
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13772
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Kang, Seung-gu,Tien Huynh,Xia, Zhen,et al. Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(8):CONCATENATE(Sheet1!I155,-Sheet1!J155).
APA Kang, Seung-gu.,Tien Huynh.,Xia, Zhen.,Zhang, Yi.,Fang, Haiping.,...&Zhou, Ruhong.(2013).Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(8),CONCATENATE(Sheet1!I155,-Sheet1!J155).
MLA Kang, Seung-gu,et al."Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.8(2013):CONCATENATE(Sheet1!I155,-Sheet1!J155).
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