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| Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides | |
| Kang, Seung-gu; Tien Huynh; Xia, Zhen; Zhang, Yi（张益）; Fang, Haiping（方海平）; Wei, Guanghong; Zhou, Ruhong | |
| 2013 | |
| Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| ISSN | 0002-7863 |
| Volume | 135Issue:8Pages:CONCATENATE(Sheet1!I155,-Sheet1!J155) |
| Abstract | The molecular mechanism of epitaxial fibril formation has been investigated for GAV-9 (NH3+-VGGAV-VAGV-CONH2), an amyloid-like peptide extracted from a consensus sequence of amyloidogenic proteins, which assembles with very different morphologies, "upright" on mica and "flat" on the highly oriented pyrolytic graphite (HOPG). Our all-atom molecular dynamics simulations reveal that the strong electrostatic interaction induces the "upright" conformation on mica, whereas the hydrophobic interaction favors the "flat" conformation on HOPG. We also show that the epitaxial pattern on mica is ensured by the lattice matching between the anisotropic binding sites of the basal substrate and the molecular dimension of GAV-9, accompanied with a long-range order of well-defined beta-strands. Furthermore, the binding free energy surfaces indicate that the longitudinal assembly growth is predominantly driven by the hydrophobic interaction along the longer crystallographic unit cell direction of mica. These findings provide a molecular basis for the surface-assisted molecular assembly, which might also be useful for the design of de novo nanodevices. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000315618900048 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13772 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Kang, Seung-gu,Tien Huynh,Xia, Zhen,et al. Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(8):CONCATENATE(Sheet1!I155,-Sheet1!J155). |
| APA | Kang, Seung-gu.,Tien Huynh.,Xia, Zhen.,Zhang, Yi.,Fang, Haiping.,...&Zhou, Ruhong.(2013).Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(8),CONCATENATE(Sheet1!I155,-Sheet1!J155). |
| MLA | Kang, Seung-gu,et al."Hydrophobic Interaction Drives Surface-Assisted Epitaxial Assembly of Amyloid-like Peptides".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.8(2013):CONCATENATE(Sheet1!I155,-Sheet1!J155). |
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| Hydrophobic Interact（1573KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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