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In vivo behavior of near infrared-emitting quantum dots
Lu, Yimei; Su, Yuanyuan; Zhou, Yanfeng; Wang, Jie; Peng, Fei; Zhong, Yiling; Huang, Qing; Fan, Chunhai; He, Yao
2013
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume34Issue:17Pages:CONCATENATE(Sheet1!I166,-Sheet1!J166)
AbstractNear-infrared (NIR, 700-900 nm) fluorescent nanomaterials-based probes have shown major impacts on high-resolution and high-sensitivity bioimaging applications. Typically, NIR-emitting quantum dots (QDs) are highly promising as NIR bioprobes due to their unique optical properties. However, NIR-emitting QDs-related in vivo behavior remains unknown at present, severely limiting their wide-ranging bioapplications. Herein, we investigate short- and long-term in vivo biodistribution, pharmacokinetics, and toxicity of the NIR-emitting QDs. Particularly, we reveal that the NIR-emitting QDs are initially accumulated in liver, spleen, and lung for short-time (0.5-4 h) post-injection, and then increasingly absorbed by kidney during long-time (4-94 days) blood circulation. Obviously time-dependent biodistribution is observed: with time continues, most of NIR-emitting QDs are finally accumulated in liver and kidney; comparatively, less NIR-emitting QDs are observed in spleen, lung, and bone marrow. Furthermore, histological and biochemical analyses, and body weight measurements demonstrate that there is no overt toxicity of NIR-emitting QDs in mice even at long-time (94 days) exposure time. Our studies provide invaluable information for the design and development of NIR-emitting QDs-based nanoprobes for biological and biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000317700400012
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13779
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Lu, Yimei,Su, Yuanyuan,Zhou, Yanfeng,et al. In vivo behavior of near infrared-emitting quantum dots[J]. BIOMATERIALS,2013,34(17):CONCATENATE(Sheet1!I166,-Sheet1!J166).
APA Lu, Yimei.,Su, Yuanyuan.,Zhou, Yanfeng.,Wang, Jie.,Peng, Fei.,...&He, Yao.(2013).In vivo behavior of near infrared-emitting quantum dots.BIOMATERIALS,34(17),CONCATENATE(Sheet1!I166,-Sheet1!J166).
MLA Lu, Yimei,et al."In vivo behavior of near infrared-emitting quantum dots".BIOMATERIALS 34.17(2013):CONCATENATE(Sheet1!I166,-Sheet1!J166).
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