CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level
Zuo, Guanghong; Kang, Seung-gu; Xiu, Peng; Zhao, Yuliang; Zhou, Ruhong
2013
Source PublicationSMALL
ISSN1613-6810
Volume9Issue:41892Pages:CONCATENATE(Sheet1!I173,-Sheet1!J173)
AbstractThe widespread application of nanomaterials has spurred an interest in the study of interactions between nanoparticles and proteins due to the biosafety concerns of these nanomaterials. In this review, a summary is presented of some of the recent studies on this important subject, especially on the interactions of proteins with carbon nanotubes (CNTs) and metallofullerenols. Two potential molecular mechanisms have been proposed for CNTs' inhibition of protein functions. The driving forces of CNTs' adsorption onto proteins are found to be mainly hydrophobic interactions and the so-called stacking between CNTs' carbon rings and proteins' aromatic residues. However, there is also recent evidence showing that endohedral metallofullerenol Gd@C82(OH)22 can be used to inhibit tumor growth, thus acting as a potential nanomedicine. These recent findings have provided a better understanding of nanotoxicity at the molecular level and also suggested therapeutic potential by using nanoparticles' cytotoxicity against cancer cells.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000319076000011
Citation statistics
Cited Times:86[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13786
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zuo, Guanghong,Kang, Seung-gu,Xiu, Peng,et al. Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level[J]. SMALL,2013,9(41892):CONCATENATE(Sheet1!I173,-Sheet1!J173).
APA Zuo, Guanghong,Kang, Seung-gu,Xiu, Peng,Zhao, Yuliang,&Zhou, Ruhong.(2013).Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level.SMALL,9(41892),CONCATENATE(Sheet1!I173,-Sheet1!J173).
MLA Zuo, Guanghong,et al."Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level".SMALL 9.41892(2013):CONCATENATE(Sheet1!I173,-Sheet1!J173).
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