Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level | |
| Zuo, Guanghong; Kang, Seung-gu; Xiu, Peng; Zhao, Yuliang; Zhou, Ruhong | |
| 2013 | |
| Source Publication | SMALL
 |
| ISSN | 1613-6810 |
| Volume | 9Issue:41892Pages:CONCATENATE(Sheet1!I173,-Sheet1!J173) |
| Abstract | The widespread application of nanomaterials has spurred an interest in the study of interactions between nanoparticles and proteins due to the biosafety concerns of these nanomaterials. In this review, a summary is presented of some of the recent studies on this important subject, especially on the interactions of proteins with carbon nanotubes (CNTs) and metallofullerenols. Two potential molecular mechanisms have been proposed for CNTs' inhibition of protein functions. The driving forces of CNTs' adsorption onto proteins are found to be mainly hydrophobic interactions and the so-called stacking between CNTs' carbon rings and proteins' aromatic residues. However, there is also recent evidence showing that endohedral metallofullerenol Gd@C82(OH)22 can be used to inhibit tumor growth, thus acting as a potential nanomedicine. These recent findings have provided a better understanding of nanotoxicity at the molecular level and also suggested therapeutic potential by using nanoparticles' cytotoxicity against cancer cells. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000319076000011 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13786 |
| Collection | 中科院上海应用物理研究所2011-2018年 |
| Recommended Citation GB/T 7714 | Zuo, Guanghong,Kang, Seung-gu,Xiu, Peng,et al. Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level[J]. SMALL,2013,9(41892):CONCATENATE(Sheet1!I173,-Sheet1!J173). |
| APA | Zuo, Guanghong,Kang, Seung-gu,Xiu, Peng,Zhao, Yuliang,&Zhou, Ruhong.(2013).Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level.SMALL,9(41892),CONCATENATE(Sheet1!I173,-Sheet1!J173). |
| MLA | Zuo, Guanghong,et al."Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level".SMALL 9.41892(2013):CONCATENATE(Sheet1!I173,-Sheet1!J173). |
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| File Name/Size | DocType | Version | Access | License | ||
| Interactions Between（1723KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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