CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism
Tian, Liting; Zheng, Guang; Sommar, Johan Nilsson; Liang, Yihuai; Lundh, Tomas; Broberg, Karin; Lei, Lijian; Guo, Weijun; Li, Yulan; Tan, Mingguang; Skerfving, Staffan; Jin, Taiyi; Bergdahl, Ingvar A.
2013
Source PublicationTOXICOLOGY LETTERS
ISSN0378-4274
Volume221Issue:2Pages:CONCATENATE(Sheet1!I194,-Sheet1!J194)
AbstractBlood lead concentration (B-Pb), the main biomarker of lead exposure and risk, is curvi-linearily related to exposure. We assessed plasma lead (P-Pb) as a marker for both lead exposure and toxic effects. We examined claims that delta-aminolevulinic acid dehydratase genotype (ALAD) can modify lead toxicity. In 290 lead-exposed and 91 unexposed Chinese workers, we determined P-Pb, B-Pb, urinary lead (U-Pb), AMD polymorphism (rs1800435, ALAD112; TaqMan assay), and also toxic effects on heme synthesis (blood zinc protoporphyrin and hemoglobin, urinary delta-aminolevulic acid), on the kidneys (urinary albumin, beta(2)microglobulin and N-acetyl-beta-D-glucosaminidase) and on the peripheral nervous system (sensory and motor conduction velocities).In exposed workers, median P-Pb was 4.10 (range 0.35-27) mu g/L, B-Pb 401 (110-950) mu g/L, and U-Pb 188 (22-590) mu g/g creatinine. P-Pb had a higher ratio between exposed and unexposed workers (median 39, range 18-110) than B-Pb (19, 15-36; p<0.001) and U-Pb (28, 15-36; p<0.001). All three biomarkers were associated with all toxic effects (P-Pb: r(s)= -0.10 to 0.79; B-Pb: r(s) = -0.08 to 0.75; all p <0.05). In the exposed workers, B-Pb and U-Pb were significantly higher (p = 0.04) in AIAD2 carriers (7% in the exposed population) than in ALAD1 homozygotes. P-Pb values were similar; ALAD1 homozygotes suffered higher kidney toxicity at the same P-Pb.Conclusions: (i) P-Pb has advantages over B-Pb as a biomarker of high Pb exposure, but it was not significantly better as an index of risk of toxicity. (ii) The ALAD genotype modifies toxicokinetics and toxicodynamics. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000323087000004
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13806
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Tian, Liting,Zheng, Guang,Sommar, Johan Nilsson,et al. Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism[J]. TOXICOLOGY LETTERS,2013,221(2):CONCATENATE(Sheet1!I194,-Sheet1!J194).
APA Tian, Liting.,Zheng, Guang.,Sommar, Johan Nilsson.,Liang, Yihuai.,Lundh, Tomas.,...&Bergdahl, Ingvar A..(2013).Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism.TOXICOLOGY LETTERS,221(2),CONCATENATE(Sheet1!I194,-Sheet1!J194).
MLA Tian, Liting,et al."Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by delta-aminolevulinic acid dehydratase gene polymorphism".TOXICOLOGY LETTERS 221.2(2013):CONCATENATE(Sheet1!I194,-Sheet1!J194).
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