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Local Compression Properties of Double-Stranded DNA Based on a Dynamic Simulation
Lei Xiao-Ling; Qi Wen-Peng; Fang Hai-Ping
2013
Source PublicationCHINESE PHYSICS LETTERS
ISSN0256-307X; 1741-3540
Volume30Issue:12
AbstractUsing a simple sphere-tip compression system, the local radial mechanical properties of DNA are systematically studied by changing the tip size. When the tip size decreases, the radial compression elastic properties under external loads become sensitive to the tip size and the local DNA conformation. A sudden force break appears in the compression-force curve when the tip size is less than or equal to 12 nm in diameter. The analysis of the hydrogen bonds and the base stacking interaction shows that a local unwinding process occurs. During the compression process, firstly the hydrogen bonds between complement base pairs are broken. With the compression accumulating, the local backbones in the compression center are unwound from the double helix conformation to a kind of parallel conformation. This local unwinding behavior deduced by external loads is helpful to understand the biological process and is important to DNA-based nanomechanical devices.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000329283000046
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13810
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Lei Xiao-Ling,Qi Wen-Peng,Fang Hai-Ping. Local Compression Properties of Double-Stranded DNA Based on a Dynamic Simulation[J]. CHINESE PHYSICS LETTERS,2013,30(12).
APA Lei Xiao-Ling,Qi Wen-Peng,&Fang Hai-Ping.(2013).Local Compression Properties of Double-Stranded DNA Based on a Dynamic Simulation.CHINESE PHYSICS LETTERS,30(12).
MLA Lei Xiao-Ling,et al."Local Compression Properties of Double-Stranded DNA Based on a Dynamic Simulation".CHINESE PHYSICS LETTERS 30.12(2013).
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