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Mechanical force-induced DNA damage during AFM single-molecule manipulation
Zhang Chen; Duan Na; Dai Bin; Zhang Yi; Zhang Donghua; Hu Jun
2013
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042; 2210-3147
Volume24Issue:3
AbstractMany environmental factors can cause DNA damage, such as radiation, heat, oxygen free radical, etc., which can induce mutation during DNA replication. Meanwhile, DNA molecules are subjected to various mechanical forces in numerous biological processes. However, it is unknown whether the mechanical force would induce DNA damage and introduce mutation during DNA replication. With the combination of single-molecule manipulation based on atomic force microscopy (AFM), single molecular polymerase chain reaction (SM-PCR) and Sanger's sequencing, we investigated the effect of mechanical force on DNA. The results show that mechanical force can cause DNA damage and induce DNA mutation during amplification.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000328921800011
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13816
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhang Chen,Duan Na,Dai Bin,et al. Mechanical force-induced DNA damage during AFM single-molecule manipulation[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(3).
APA Zhang Chen,Duan Na,Dai Bin,Zhang Yi,Zhang Donghua,&Hu Jun.(2013).Mechanical force-induced DNA damage during AFM single-molecule manipulation.NUCLEAR SCIENCE AND TECHNIQUES,24(3).
MLA Zhang Chen,et al."Mechanical force-induced DNA damage during AFM single-molecule manipulation".NUCLEAR SCIENCE AND TECHNIQUES 24.3(2013).
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