CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles
Chu, Maoquan; Shao, Yuxiang; Peng, Jinliang; Dai, Xiangyun; Li, Haikuo; Wu, Qingsheng; Shi, Donglu
2013
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume34Issue:16Pages:CONCATENATE(Sheet1!I226,-Sheet1!J226)
AbstractThe photothermal effect of Fe3O4 magnetic nanoparticles is investigated for cancer therapy both in vitro and in vivo experiments. Heat is found to be rapidly generated by red and near-infrared (NIR) range laser irradiation of Fe3O4 nanoparticles with spherical, hexagonal and wire-like shapes. These Fe3O4 nanoparticles are coated with carboxyl-terminated poly (ethylene glycol)-phospholipid for enhanced dispersion in water. The surface-functionalized Fe3O4 nanoparticles can be taken up by esophageal cancer cells and do not obviously affect the cell structure and viability. Upon irradiation at 808 nm however, the esophageal cancer cell viability is effectively suppressed, and the cellular organelles are obviously damaged when incubated with the NIR laser activated Fe3O4 nanoparticles. Mouse esophageal tumor growth was found to be significantly inhibited by the photothermal effect of Fe3O4 nanoparticles, resulting in effective tumor reduction. A morphological examination revealed that after a photothermal therapy, the tumor tissue structure exhibited discontinuation, the cells were significantly shriveled and some cells have finally disintegrated. (c) 2013 Elsevier Ltd. All rights reserved.Z
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000317322600015
Citation statistics
Cited Times:226[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13833
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Chu, Maoquan,Shao, Yuxiang,Peng, Jinliang,et al. Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles[J]. BIOMATERIALS,2013,34(16):CONCATENATE(Sheet1!I226,-Sheet1!J226).
APA Chu, Maoquan.,Shao, Yuxiang.,Peng, Jinliang.,Dai, Xiangyun.,Li, Haikuo.,...&Shi, Donglu.(2013).Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles.BIOMATERIALS,34(16),CONCATENATE(Sheet1!I226,-Sheet1!J226).
MLA Chu, Maoquan,et al."Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles".BIOMATERIALS 34.16(2013):CONCATENATE(Sheet1!I226,-Sheet1!J226).
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