CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Phosphate Base Effect on DNA Damage Photo-Induced by Ciprofloxacin
Liu Yan-Cheng; Li Hai-Xia; Cui Rong-Rong; Xu Yu-Lie; Wang Wen-Feng
2013
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume29Issue:1Pages:CONCATENATE(Sheet1!I250,-Sheet1!J250)
AbstractStable and transient spectroscopic studies were conducted to investigate the influence of DNA phosphate bases in the process of DNA damage photo-induced by ciprofloxacin (CPX). The results of UV-visible and fluorescence studies confirmed that the absorption and emission properties of CPX were affected by the concentration of phosphate buffer (PB), and these results indicated that there are interactions between CPX and the phosphate anion. To investigate the relationship between the phosphate base and CPX, a comparative experiment was conducted using guanosine (Gua), 2'-deoxyguanosine (dG), and 2'-deoxyguanosine-5'-monophosphate (dGMP). By comparative experiments, we found that the type of spectrum of CPX triplet state was changed due to the phosphate base of dGMP, hence, we concluded that the photo-damage process was changed. The effects of phosphate base of dGMP on the CPX triplet state ((CPX)-C-3*) spectrum have been investigated by laser flash photolysis methods, and the results confirmed that there are hydrogen-bonding interactions between the phosphate base of dGMP and CPX. In this study, we found that CPX and dGMP are combined together by the hydrogen bond which changed the mode of DNA damage photo-induced by CPX. Finally, based on the results obtained in this study, a rational scheme to describe the role of phosphate base playing in the DNA damage process photo-induced by CPX is proposed.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000312711700029
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13854
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Liu Yan-Cheng,Li Hai-Xia,Cui Rong-Rong,et al. Phosphate Base Effect on DNA Damage Photo-Induced by Ciprofloxacin[J]. ACTA PHYSICO-CHIMICA SINICA,2013,29(1):CONCATENATE(Sheet1!I250,-Sheet1!J250).
APA Liu Yan-Cheng,Li Hai-Xia,Cui Rong-Rong,Xu Yu-Lie,&Wang Wen-Feng.(2013).Phosphate Base Effect on DNA Damage Photo-Induced by Ciprofloxacin.ACTA PHYSICO-CHIMICA SINICA,29(1),CONCATENATE(Sheet1!I250,-Sheet1!J250).
MLA Liu Yan-Cheng,et al."Phosphate Base Effect on DNA Damage Photo-Induced by Ciprofloxacin".ACTA PHYSICO-CHIMICA SINICA 29.1(2013):CONCATENATE(Sheet1!I250,-Sheet1!J250).
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