CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study
Liu, Yancheng; Zhang, Peng; Li, Haixia; Tang, Ruizhi; Cui, Rong Rong; Wang, Wenfeng
2013
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume118Pages:CONCATENATE(Sheet1!I251,-Sheet1!J251)
AbstractPhotochemical properties and phototoxicity of Pazufloxacin (PAX) were systematically investigated in aqueous solutions using UV-Vis, fluorescence, laser flash photolysis, pulse radiolysis and SDS-PAGE gel electrophoresis techniques. PAX triplet-state (SPA)((3)PAX*) absorption spectra (lambda(max) = 570 nm) was determined. (3)PAX* was quenched by PAX and O-2, with rate constants of 6.9 x 10(8) and 3.2 x 10(8) dm(3) mol(-1) s(-1), respectively. The pK(a) values (5.7 and 8.6) for the protonation equilibrium were determined by UV-Vis and fluorescence techniques. The PAX triplet energy (E-T = 260.3 kJ/mol) was obtained using energy transfer method. The reaction of electron transfer from tryptophan (TrpH) and dGMP to (3)PAX* was found with rate constants of 8.8 x 10(7) and 8.7 x 10(6) dm(3) mol(-1) s(-1), respectively. The rate constants for reactions of center dot OH, SO4-center dot; and hydrated electron with PAX were found to be 5.8 x 10(8), 2.1 x 10(8) and 9 x 10(9) dm(3) mol(-1) s(-1), respectively. Based on the results obtained, a rational scheme for dGMP, TrpH and lysozyme photodamage induced by PAX was proposed. (C) 2012 Elsevier B.V. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000314258800008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13855
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Liu, Yancheng,Zhang, Peng,Li, Haixia,et al. Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2013,118:CONCATENATE(Sheet1!I251,-Sheet1!J251).
APA Liu, Yancheng,Zhang, Peng,Li, Haixia,Tang, Ruizhi,Cui, Rong Rong,&Wang, Wenfeng.(2013).Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,118,CONCATENATE(Sheet1!I251,-Sheet1!J251).
MLA Liu, Yancheng,et al."Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 118(2013):CONCATENATE(Sheet1!I251,-Sheet1!J251).
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