CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Scaffolded biosensors with designed DNA nanostructures
Pei, Hao; Zuo, Xiaolei; Pan, Dun; Shi, Jiye; Huang, Qing; Fan, Chunhai
2013
Source PublicationNPG ASIA MATERIALS
ISSN1884-4049
Volume5
AbstractIn addition to its fundamental function as a genetic code carrier, the utilization of DNA in various material applications has been actively explored over the past several decades. DNA is intrinsically an excellent type of self-assembly nanomaterial owing to its predictable base-pairing, high chemical stability and the convenience it possesses for synthesis and modification. Because of these unparalleled properties, DNA is widely used as excellent recognition elements in biosensors and as unique building blocks in nanodevices. A critical challenge in surface-based DNA biosensors lies in the reduced accessibility of target molecules to the DNA probes arranged on heterogeneous surfaces, especially when compared to probe-target recognition in homogeneous solutions. To improve the recognition abilities of these heterogeneous surface-confined DNA probes, much effort has been devoted to controlling the surface chemistry, conformation and packing density of the probe molecules, as well as the size and geometry of the surface. In this review, we aim to summarize the recent progress on the improvement of the probe-target recognition properties by introducing DNA nanostructure scaffolds. A range of new strategies have proven to provide a significantly enhanced range in the spatial positioning and the accessibility of the probes to the surface over previously reported linear structures. We will also describe the applications of DNA nanostructure scaffold-based biosensors.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000321108400002
Citation statistics
Cited Times:72[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13893
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Pei, Hao,Zuo, Xiaolei,Pan, Dun,et al. Scaffolded biosensors with designed DNA nanostructures[J]. NPG ASIA MATERIALS,2013,5.
APA Pei, Hao,Zuo, Xiaolei,Pan, Dun,Shi, Jiye,Huang, Qing,&Fan, Chunhai.(2013).Scaffolded biosensors with designed DNA nanostructures.NPG ASIA MATERIALS,5.
MLA Pei, Hao,et al."Scaffolded biosensors with designed DNA nanostructures".NPG ASIA MATERIALS 5(2013).
Files in This Item: Download All
File Name/Size DocType Version Access License
Scaffolded biosensor(2300KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Pei, Hao]'s Articles
[Zuo, Xiaolei]'s Articles
[Pan, Dun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Pei, Hao]'s Articles
[Zuo, Xiaolei]'s Articles
[Pan, Dun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Pei, Hao]'s Articles
[Zuo, Xiaolei]'s Articles
[Pan, Dun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Scaffolded biosensors with designed DNA nanostructures.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.