CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Size-Dependent Cytotoxicity of Nanocarbon Blacks
Kong, Huating; Zhang, Yu; Li, Yongjun; Cui, Zhifen; Xia, Kai; Sun, Yanhong; Zhao, Qunfen; Zhu, Ying
AbstractIn this study, we investigated the toxic effects of nanocarbon blacks (NCBs) with different sizes to mouse macrophage RAW264.7 cells. MTT and fluorescence-based LIVE assays demonstrated that NCBs uptake caused a size and dose-dependent growth inhibition to the cells. Optical microscopy observations and Tc-99m radionuclide labeling techniques were used to investigate the cellular uptake of NCBs with different sizes qualitatively and quantitatively, respectively. Results showed that the cellular uptake amounts of NCBs increased with their increasing size. Large quantities of internal NCBs induced oxidative stress and nuclear damage in cells; these effects may be the critical factors involved in the cytotoxicity of NCBs. The implications associated with these findings are discussed.
Indexed BySCI
Funding Project应物所项目组
WOS IDWOS:000328624400079
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Document Type期刊论文
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GB/T 7714
Kong, Huating,Zhang, Yu,Li, Yongjun,et al. Size-Dependent Cytotoxicity of Nanocarbon Blacks[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(11):CONCATENATE(Sheet1!I305,-Sheet1!J305).
APA Kong, Huating.,Zhang, Yu.,Li, Yongjun.,Cui, Zhifen.,Xia, Kai.,...&Zhu, Ying.(2013).Size-Dependent Cytotoxicity of Nanocarbon Blacks.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,14(11),CONCATENATE(Sheet1!I305,-Sheet1!J305).
MLA Kong, Huating,et al."Size-Dependent Cytotoxicity of Nanocarbon Blacks".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14.11(2013):CONCATENATE(Sheet1!I305,-Sheet1!J305).
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