CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures
Li, Jiang; Fan, Chunhai; Pei, Hao; Shi, Jiye; Huang, Qing
2013
Source PublicationADVANCED MATERIALS
ISSN0935-9648; 1521-4095
Volume25Issue:32Pages:CONCATENATE(Sheet1!I308,-Sheet1!J308)
AbstractSelf-assembled DNA nanostructures have emerged as a type of nano-biomaterials with precise structures, versatile functions and numerous applications. One particularly promising application of these DNA nanostructures is to develop universal nanocarriers for smart and targeted drug delivery. DNA is the genetic material in nature, and inherently biocompatible. Nevertheless, cell membranes are barely permeable to naked DNA molecules, either single- or double- stranded; transport across the cell membrane is only possible with the assistance of transfection agents. Interestingly, recent studies revealed that many DNA nanostructures could readily go into cells with high cell uptake efficiency. In this Progress Report, we will review recent advances on using various DNA nanostructures, e.g., DNA nanotubes, DNA tetrahedra, and DNA origami nanorobot, as drug delivery nanocarriers, and demonstrate several examples aiming at therapeutic applications with CpG-based immunostimulatory and siRNA-based gene silencing oligonucleotides.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000327749600001
Citation statistics
Cited Times:228[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13908
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Li, Jiang,Fan, Chunhai,Pei, Hao,et al. Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures[J]. ADVANCED MATERIALS,2013,25(32):CONCATENATE(Sheet1!I308,-Sheet1!J308).
APA Li, Jiang,Fan, Chunhai,Pei, Hao,Shi, Jiye,&Huang, Qing.(2013).Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures.ADVANCED MATERIALS,25(32),CONCATENATE(Sheet1!I308,-Sheet1!J308).
MLA Li, Jiang,et al."Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures".ADVANCED MATERIALS 25.32(2013):CONCATENATE(Sheet1!I308,-Sheet1!J308).
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