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| Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry | |
| Wang Cheng; Yin Jilin; Zhou Wei; Zhang Lan; Zhou Zheng | |
| 2013 | |
| Source Publication | NUCLEAR SCIENCE AND TECHNIQUES
 |
| ISSN | 1001-8042; 2210-3147 |
| Volume | 24Issue:3 |
| Abstract | Click chemistry was used to study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+). CuSO4/L-sodium ascorbate was chosen as the catalyst system, three terminal alkynes were conjugated with two different azides respectively, and then the new prepared fac-[Re-188(CO)(3)(H2O)(3)](+) was coordinated to the six triazoles. The results showed that the radiochemical yields (RCY) of the conjugation of fac-[Re-188(CO)(3)](+) with six triazoles were over 90%, and the triazoles showed high stability in phosphate-buffered saline and new-born calf serum. The preliminary biological evaluation results showed that the new Re-188-labeling method via click chemistry could have general application in labeling bioactive molecules in high radiochemical yield and high specific activity for further SPECT research. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000328921800004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13931 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Recommended Citation GB/T 7714 | Wang Cheng,Yin Jilin,Zhou Wei,et al. Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(3). |
| APA | Wang Cheng,Yin Jilin,Zhou Wei,Zhang Lan,&Zhou Zheng.(2013).Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry.NUCLEAR SCIENCE AND TECHNIQUES,24(3). |
| MLA | Wang Cheng,et al."Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry".NUCLEAR SCIENCE AND TECHNIQUES 24.3(2013). |
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