CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry
Wang Cheng; Yin Jilin; Zhou Wei; Zhang Lan; Zhou Zheng
2013
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042; 2210-3147
Volume24Issue:3
AbstractClick chemistry was used to study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+). CuSO4/L-sodium ascorbate was chosen as the catalyst system, three terminal alkynes were conjugated with two different azides respectively, and then the new prepared fac-[Re-188(CO)(3)(H2O)(3)](+) was coordinated to the six triazoles. The results showed that the radiochemical yields (RCY) of the conjugation of fac-[Re-188(CO)(3)](+) with six triazoles were over 90%, and the triazoles showed high stability in phosphate-buffered saline and new-born calf serum. The preliminary biological evaluation results showed that the new Re-188-labeling method via click chemistry could have general application in labeling bioactive molecules in high radiochemical yield and high specific activity for further SPECT research.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000328921800004
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13931
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Wang Cheng,Yin Jilin,Zhou Wei,et al. Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(3).
APA Wang Cheng,Yin Jilin,Zhou Wei,Zhang Lan,&Zhou Zheng.(2013).Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry.NUCLEAR SCIENCE AND TECHNIQUES,24(3).
MLA Wang Cheng,et al."Study on radiolabeling of 1,2,3-triazole analogs with fac-[Re-188(CO)(3)(H2O)(3)](+) via click chemistry".NUCLEAR SCIENCE AND TECHNIQUES 24.3(2013).
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