CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Terahertz identification and quantification of penicillamine enantiomers
Ji Te; Zhao Hongwei; Han Pengyu; Chen Min; Xiao Tiqiao
2013
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042; 2210-3147
Volume24Issue:1
AbstractIdentification and characterization of L-, D- and DL- penicillamine were demonstrated by Terahertz time-domain spectroscopy (THz-TDS). To understand the physical origins of the low frequency resonant modes, the density functional theory (DFT) was adopted for theoretical calculation. It was found that the collective THz frequency motions were decided by the intramolecular and intermolecular hydrogen bond interactions. Moreover, the quantification of penicillamine enantiomers mixture was demonstrated by a THz spectra fitting method with a relative error of less than 3.5%. This technique can be a valuable tool for the discrimination and quantification of chiral drugs in pharmaceutical industry.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000328921400003
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13949
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Ji Te,Zhao Hongwei,Han Pengyu,et al. Terahertz identification and quantification of penicillamine enantiomers[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(1).
APA Ji Te,Zhao Hongwei,Han Pengyu,Chen Min,&Xiao Tiqiao.(2013).Terahertz identification and quantification of penicillamine enantiomers.NUCLEAR SCIENCE AND TECHNIQUES,24(1).
MLA Ji Te,et al."Terahertz identification and quantification of penicillamine enantiomers".NUCLEAR SCIENCE AND TECHNIQUES 24.1(2013).
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