Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Terahertz identification and quantification of penicillamine enantiomers | |
| Ji Te; Zhao Hongwei; Han Pengyu; Chen Min; Xiao Tiqiao | |
| 2013 | |
| Source Publication | NUCLEAR SCIENCE AND TECHNIQUES
 |
| ISSN | 1001-8042; 2210-3147 |
| Volume | 24Issue:1 |
| Abstract | Identification and characterization of L-, D- and DL- penicillamine were demonstrated by Terahertz time-domain spectroscopy (THz-TDS). To understand the physical origins of the low frequency resonant modes, the density functional theory (DFT) was adopted for theoretical calculation. It was found that the collective THz frequency motions were decided by the intramolecular and intermolecular hydrogen bond interactions. Moreover, the quantification of penicillamine enantiomers mixture was demonstrated by a THz spectra fitting method with a relative error of less than 3.5%. This technique can be a valuable tool for the discrimination and quantification of chiral drugs in pharmaceutical industry. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000328921400003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/13949 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Ji Te,Zhao Hongwei,Han Pengyu,et al. Terahertz identification and quantification of penicillamine enantiomers[J]. NUCLEAR SCIENCE AND TECHNIQUES,2013,24(1). |
| APA | Ji Te,Zhao Hongwei,Han Pengyu,Chen Min,&Xiao Tiqiao.(2013).Terahertz identification and quantification of penicillamine enantiomers.NUCLEAR SCIENCE AND TECHNIQUES,24(1). |
| MLA | Ji Te,et al."Terahertz identification and quantification of penicillamine enantiomers".NUCLEAR SCIENCE AND TECHNIQUES 24.1(2013). |
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| File Name/Size | DocType | Version | Access | License | ||
| Terahertz identifica（260KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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