Ultra-sensitive nucleic acids detection with electrical nanosensors based on CMOS-compatible silicon nanowire field-effect transistors

CAS OpenIR > 中科院上海应用物理研究所2011-2019年

	Ultra-sensitive nucleic acids detection with electrical nanosensors based on CMOS-compatible silicon nanowire field-effect transistors
	Lu, Na; Gao, Anran; Dai, Pengfei; Li, Tie; Wang, Yi; Gao, Xiuli; Song, Shiping; Fan, Chunhai; Wang, Yuelin
	2013
Source Publication	METHODS
ISSN	1046-2023; 1095-9130
Volume	63 Issue:3 Pages:CONCATENATE(Sheet1!I384,-Sheet1!J384)
Abstract	Silicon nanowire field-effect transistors (SiNW-FETs) have recently emerged as a type of powerful nanoelectronic biosensors due to their ultrahigh sensitivity, selectivity, label-free and real-time detection capabilities. Here, we present a protocol as well as guidelines for detecting DNA with complementary metal oxide semiconductor (CMOS) compatible SiNW-FET sensors. SiNWs with high surface-to-volume ratio and controllable sizes were fabricated with an anisotropic self-stop etching technique. Probe DNA molecules specific for the target DNA were covalently modified onto the surface of the SiNWs. The SiNW-FET nanosensors exhibited an ultrahigh sensitivity for detecting the target DNA as low as 1 fM and good selectivity for discrimination from one-base mismatched DNA. (C) 2013 Elsevier Inc. All rights reserved.
Indexed By	SCI
Language	英语
Funding Project	应物所项目组
WOS ID	WOS:000326135800003
Citation statistics	Cited Times:16[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/13978
Collection	中科院上海应用物理研究所2011-2019年
Recommended Citation GB/T 7714	Lu, Na,Gao, Anran,Dai, Pengfei,et al. Ultra-sensitive nucleic acids detection with electrical nanosensors based on CMOS-compatible silicon nanowire field-effect transistors[J]. METHODS,2013,63(3):CONCATENATE(Sheet1!I384,-Sheet1!J384).
APA	Lu, Na.,Gao, Anran.,Dai, Pengfei.,Li, Tie.,Wang, Yi.,...&Wang, Yuelin.(2013).Ultra-sensitive nucleic acids detection with electrical nanosensors based on CMOS-compatible silicon nanowire field-effect transistors.METHODS,63(3),CONCATENATE(Sheet1!I384,-Sheet1!J384).
MLA	Lu, Na,et al."Ultra-sensitive nucleic acids detection with electrical nanosensors based on CMOS-compatible silicon nanowire field-effect transistors".METHODS 63.3(2013):CONCATENATE(Sheet1!I384,-Sheet1!J384).

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