CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction
Liu, Ruihao; Yin, Xianzhen; Li, Haiyan; Shao, Qun; York, Peter; He, You; Xiao, Tiqiao; Zhang, Jiwen
2013
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
Volume445Issue:41641Pages:CONCATENATE(Sheet1!I390,-Sheet1!J390)
AbstractTomographic imaging techniques have great potential for improving understanding of the dynamics of granular materials during manufacturing, handling, and storage. In this study, the synchrotron radiation X-ray computed microtomography (SR-mu CT) was used non-invasively to monitor blend homogeneity of binary mixtures. Granular samples of microcrystalline cellulose and starch were characterized using the SR-mu CT individually. Simultaneously, particle distribution was investigated by calculating the frequency distribution of a statistic for testing sphericity. Then, the microcrystalline cellulose and starch granules were blended in a cylindrical container. Influences of the time of rotations T-R and the time of vibration TV on the mixture homogeneity were studied with the SR-mu CT and statistical evaluation. The mixing index is also adopted to evaluate the mixture homogeneity of the particle system. The results showed that mixture homogeneity is improved with increasing TR. Furthermore, segregation increased with longer TV when particles are different in size and shape. The larger starch granules of non-spherical shape have a tendency to rise to the top, while the smaller microcrystalline cellulose granules which are spherical tend to migrate to the bottom of the mixture. Therefore, we demonstrate that SR-mu CT can investigate the mixing and segregation of granular materials in three-dimensions combined with statistic method. (C) 2013 Elsevier B.V. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000315947300015
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/13984
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Liu, Ruihao,Yin, Xianzhen,Li, Haiyan,et al. Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,445(41641):CONCATENATE(Sheet1!I390,-Sheet1!J390).
APA Liu, Ruihao.,Yin, Xianzhen.,Li, Haiyan.,Shao, Qun.,York, Peter.,...&Zhang, Jiwen.(2013).Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction.INTERNATIONAL JOURNAL OF PHARMACEUTICS,445(41641),CONCATENATE(Sheet1!I390,-Sheet1!J390).
MLA Liu, Ruihao,et al."Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction".INTERNATIONAL JOURNAL OF PHARMACEUTICS 445.41641(2013):CONCATENATE(Sheet1!I390,-Sheet1!J390).
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