CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Aerosol inhalation exposure study of respiratory toxicity induced by 20 nm anatase titanium dioxide nanoparticles
Yin, JL; Kang, C; Li, YF; Li, QN; Zhang, XY; Li, WX; liqingnuan@sinap.ac.cn; xiaoyongzhang1980@gmail.com
2014
Source PublicationTOXICOLOGY RESEARCH
ISSN2045-452X
Volume3Issue:5Pages:367—374
AbstractWith the rapid development of nanoscience and nanotechnology, comprehensive evaluation of the potential toxicity especially the respiratory toxicity of nanomaterials, has attracted great research interest over the past few decades. A numerous previous reports have utilized intratracheal instillation to imitate the physiological inhalation exposure route of nanomaterials. However, because it is a non-physiological breathing process, intratracheal instillation has many problems when it is utilized to evaluate respiratory toxicity of nanomaterials. In this study, anatase titanium dioxide (TiO2) nanoparticles with a primary particle size of 20 nm was selected as a model nanomaterial. Its respiratory toxicity has been estimated by a whole-body exposure chamber. Mice were put in the whole-body exposure chambers with a relatively steady concentration (6.34 +/- 0.22 mg m(-3)) of inhaled TiO2 nanoparticles. In the whole study these mice were exposed 8 h per day, for 3 weeks. Results showed that these TiO2 nanoparticles inhaled might drill through air-blood barriers, be metabolized by the liver and excreted by the urinary system. After mice had been exposed to TiO2 nanoparticles, H2O2 and maleic dialdehyde (MDA) in brain homogenate extracts had clearly increased. The white blood cell (WBC) count was decreased while platelet (PLT) and reticulocyte (Retic) counts increased significantly. At the same time, the prothrombin time (PT) of mice in the inhalation exposure group was shorter than the control group's. Furthermore, compared with the control group's, the levels of ALT, AST, BUN and CREA in the inhalation exposure group were elevated. Given the whole body exposure method is a physiological exposure route, the results reported in this work should be more suitable for evaluation of the respiratory toxicity of nanomaterials.
KeywordWalled Carbon Nanotubes Fluorescent Organic Nanoparticles Cell Imaging Applications Metallized Tio2 Suspensions Graphene Oxide Intratracheal Instillation Photocatalyzed Oxidation Chemotherapeutic Drug Pulmonary Toxicity Particle-size
Indexed BySCI
Language英语
WOS IDWOS:000340207800009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14004
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorliqingnuan@sinap.ac.cn; xiaoyongzhang1980@gmail.com
Recommended Citation
GB/T 7714
Yin, JL,Kang, C,Li, YF,et al. Aerosol inhalation exposure study of respiratory toxicity induced by 20 nm anatase titanium dioxide nanoparticles[J]. TOXICOLOGY RESEARCH,2014,3(5):367—374.
APA Yin, JL.,Kang, C.,Li, YF.,Li, QN.,Zhang, XY.,...&xiaoyongzhang1980@gmail.com.(2014).Aerosol inhalation exposure study of respiratory toxicity induced by 20 nm anatase titanium dioxide nanoparticles.TOXICOLOGY RESEARCH,3(5),367—374.
MLA Yin, JL,et al."Aerosol inhalation exposure study of respiratory toxicity induced by 20 nm anatase titanium dioxide nanoparticles".TOXICOLOGY RESEARCH 3.5(2014):367—374.
Files in This Item: Download All
File Name/Size DocType Version Access License
Aerosol inhalation e(2750KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yin, JL]'s Articles
[Kang, C]'s Articles
[Li, YF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yin, JL]'s Articles
[Kang, C]'s Articles
[Li, YF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yin, JL]'s Articles
[Kang, C]'s Articles
[Li, YF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Aerosol inhalation exposure study of respiratory toxicity induced by 20 nm anatase titanium dioxide nanoparticles.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.