CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury
Ma, HL; Ning, J; Jin, X; Mao, CM; Bu, XL; Wang, M; Liu, H; Wang, K; Lausted, C; Hood, L; Chen, JK; Hu, ZY; mahuailei@nanoctr.cn; 13366152125@163.com; chenjiankui@hotmail.com; huzy@nanoctr.cn
2014
Source PublicationBIOMARKERS
ISSN1354-750X
Volume19Issue:7Pages:578—584
AbstractWe developed a high-performance ELISA assay and measured serum BHMT levels in healthy individuals and patients with acute liver injury (ALI). The detection range of this ELISA assay was from 1.56 to 100 ng/ml. BHMT levels are significantly higher in ALI groups. In the healthy group (n = 244), the median value (interquartile range, IQR 0-56.40) was 1.83 ng/ml. In the ALI group (n = 42), the median value of BHMT was 748.48 ng/ml (IQR, 0-51095.92). ROC curve analysis demonstrated good sensitivity (0.86) and specificity (0.98). In addition, in five ALI cases with time course samples available, BHMT and ALT both followed the "rise and fall'' temporal pattern with the disease progression. However, the slopes of BHMT curves were steeper than ALT curves. And in three out of the five cases, BHMT levels peaked 1 day earlier than ALT levels be a sensitive marker with good prognostic value.
KeywordAlanine Aminotransferase Methionine Metabolism S-methyltransferase Serum Disease Elisa Alt Hepatotoxicity Validation Expression
Indexed BySCI
Language英语
WOS IDWOS:000344003400008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14024
Collection中科院上海应用物理研究所2011-2020年
Corresponding Authormahuailei@nanoctr.cn; 13366152125@163.com; chenjiankui@hotmail.com; huzy@nanoctr.cn
Recommended Citation
GB/T 7714
Ma, HL,Ning, J,Jin, X,et al. Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury[J]. BIOMARKERS,2014,19(7):578—584.
APA Ma, HL.,Ning, J.,Jin, X.,Mao, CM.,Bu, XL.,...&huzy@nanoctr.cn.(2014).Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury.BIOMARKERS,19(7),578—584.
MLA Ma, HL,et al."Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury".BIOMARKERS 19.7(2014):578—584.
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