Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing | |
| Lu, N; Gao, AR; Dai, PF; Song, SP; Fan, CH; Wang, YL; Li, T; fchh@sinap.ac.cn; ylwang@mail.sim.ac.cn; tli@mail.sim.ac.cn | |
| 2014 | |
| Source Publication | SMALL
 |
| ISSN | 1613-6810 |
| Volume | 10Issue:10Pages:2022—2028 |
| Abstract | MicroRNAs (miRNAs) have been regarded as promising biomarkers for the diagnosis and prognosis of early-stage cancer as their expression levels are associated with different types of human cancers. However, it is a challenge to produce low-cost miRNA sensors, as well as retain a high sensitivity, both of which are essential factors that must be considered in fabricating nanoscale biosensors and in future biomedical applications. To address such challenges, we develop a complementary metal oxide semiconductor (CMOS)-compatible SiNW-FET biosensor fabricated by an anisotropic wet etching technology with self-limitation which provides a much lower manufacturing cost and an ultrahigh sensitivity. This nanosensor shows a rapid (< 1 minute) detection of miR-21 and miR-205, with a low limit of detection (LOD) of 1 zeptomole (ca. 600 copies), as well as an excellent discrimination for single-nucleotide mismatched sequences of tumor-associated miRNAs. To investigate its applicability in real settings, we have detected miRNAs in total RNA extracted from lung cancer cells as well as human serum samples using the nanosensors, which demonstrates their potential use in identifying clinical samples for early diagnosis of cancer. |
| Keyword | Electrical Detection Cancer Patients Expression Biosensors Rnas Nanosensors Elegans Genes Acid Dna |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000336611000019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14042 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Corresponding Author | fchh@sinap.ac.cn; ylwang@mail.sim.ac.cn; tli@mail.sim.ac.cn |
| Recommended Citation GB/T 7714 | Lu, N,Gao, AR,Dai, PF,et al. CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing[J]. SMALL,2014,10(10):2022—2028. |
| APA | Lu, N.,Gao, AR.,Dai, PF.,Song, SP.,Fan, CH.,...&tli@mail.sim.ac.cn.(2014).CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing.SMALL,10(10),2022—2028. |
| MLA | Lu, N,et al."CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing".SMALL 10.10(2014):2022—2028. |
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| CMOS-Compatible Sili（611KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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