CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing
Lu, N; Gao, AR; Dai, PF; Song, SP; Fan, CH; Wang, YL; Li, T; fchh@sinap.ac.cn; ylwang@mail.sim.ac.cn; tli@mail.sim.ac.cn
2014
Source PublicationSMALL
ISSN1613-6810
Volume10Issue:10Pages:2022—2028
AbstractMicroRNAs (miRNAs) have been regarded as promising biomarkers for the diagnosis and prognosis of early-stage cancer as their expression levels are associated with different types of human cancers. However, it is a challenge to produce low-cost miRNA sensors, as well as retain a high sensitivity, both of which are essential factors that must be considered in fabricating nanoscale biosensors and in future biomedical applications. To address such challenges, we develop a complementary metal oxide semiconductor (CMOS)-compatible SiNW-FET biosensor fabricated by an anisotropic wet etching technology with self-limitation which provides a much lower manufacturing cost and an ultrahigh sensitivity. This nanosensor shows a rapid (< 1 minute) detection of miR-21 and miR-205, with a low limit of detection (LOD) of 1 zeptomole (ca. 600 copies), as well as an excellent discrimination for single-nucleotide mismatched sequences of tumor-associated miRNAs. To investigate its applicability in real settings, we have detected miRNAs in total RNA extracted from lung cancer cells as well as human serum samples using the nanosensors, which demonstrates their potential use in identifying clinical samples for early diagnosis of cancer.
KeywordElectrical Detection Cancer Patients Expression Biosensors Rnas Nanosensors Elegans Genes Acid Dna
Indexed BySCI
Language英语
WOS IDWOS:000336611000019
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14042
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorfchh@sinap.ac.cn; ylwang@mail.sim.ac.cn; tli@mail.sim.ac.cn
Recommended Citation
GB/T 7714
Lu, N,Gao, AR,Dai, PF,et al. CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing[J]. SMALL,2014,10(10):2022—2028.
APA Lu, N.,Gao, AR.,Dai, PF.,Song, SP.,Fan, CH.,...&tli@mail.sim.ac.cn.(2014).CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing.SMALL,10(10),2022—2028.
MLA Lu, N,et al."CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing".SMALL 10.10(2014):2022—2028.
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