CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Crowdsourcing Yields a New Standard for Kinks in Protein Helices
Wilman, HR; Ebejer, JP; Shi, JY; Deane, CM; Knapp, B; knapp@stats.ox.ac.uk
2014
Source PublicationJOURNAL OF CHEMICAL INFORMATION AND MODELING
ISSN1549-9596
Volume54Issue:9Pages:2585—2593
AbstractKinks are functionally important structural features found in the a-helices of proteins. Structurally, they are points at which a helix abruptly changes direction. Current kink definition and identification methods often disagree with one another. Here we describe a crowdsourcing approach to obtain a reliable gold standard set of kinks. Using an online interface, we collected more than 10 000 classifications of 300 helices into straight, curved, or kinked categories. We found that participants were better at discriminating between straight and not-straight helices than between kinked and curved helices. Surprisingly, more obvious kinks were not necessarily identified as more localized within the helix. We present a set of 252 helices where more than 50% of the participants agree on a classification. This set can be used as a reliable gold standard to develop, train, and compare computational methods. An interactive visualization of the results is available online at http://opig.stats.ox.ac.uk/webapps/ahah/php/experiment_results.php.
KeywordTransmembrane Helices Secondary Structure Membrane-proteins Alpha-helices Proline Geometry Residue Hinges Model Game
Indexed BySCI
Language英语
WOS IDWOS:000342180400017
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14061
Collection中科院上海应用物理研究所2011-2020年
Corresponding Authorknapp@stats.ox.ac.uk
Recommended Citation
GB/T 7714
Wilman, HR,Ebejer, JP,Shi, JY,et al. Crowdsourcing Yields a New Standard for Kinks in Protein Helices[J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING,2014,54(9):2585—2593.
APA Wilman, HR,Ebejer, JP,Shi, JY,Deane, CM,Knapp, B,&knapp@stats.ox.ac.uk.(2014).Crowdsourcing Yields a New Standard for Kinks in Protein Helices.JOURNAL OF CHEMICAL INFORMATION AND MODELING,54(9),2585—2593.
MLA Wilman, HR,et al."Crowdsourcing Yields a New Standard for Kinks in Protein Helices".JOURNAL OF CHEMICAL INFORMATION AND MODELING 54.9(2014):2585—2593.
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