CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells
Jin, C; Wang, FD; Tang, Y; Zhang, XZ; Wang, JQ; Yang, YJ; chanjin1980@gmail.com; yjyang22@gmail.com
2014
Source PublicationBIOLOGICAL TRACE ELEMENT RESEARCH
ISSN0163-4984
Volume159Issue:42007Pages:393—398
AbstractGraphene and its derivatives are increasingly applied in nanoelectronics, biosensing, drug delivery, and biomedical applications. However, the information about its cytotoxicity remains limited. Herein, the distribution and cytotoxicity of graphene oxide (GO) and TiO2-graphene oxide composite (TiO2-GO composite) were evaluated in A549 cells. Cell viability and cell ultrastructure were measured. Our results indicated that GO could enter A549 cells and located in the cytoplasm and nucleus without causing any cell damage. TiO2 nanoparticles and GO would be separated after TiO2-GO composite entered A549 cells. TiO2-GO composite could induce cytotoxicity similar to TiO2 nanoparticles, which was probably attributed to oxidative stress. These results should be considered in the development of biological applications of GO and TiO2-GO composite.
KeywordMagnetic Nanoparticles Cellular Uptake Cytotoxicity Endocytosis Toxicity Films Line
Indexed BySCI
Language英语
WOS IDWOS:000337284300048
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14085
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorchanjin1980@gmail.com; yjyang22@gmail.com
Recommended Citation
GB/T 7714
Jin, C,Wang, FD,Tang, Y,et al. Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2014,159(42007):393—398.
APA Jin, C.,Wang, FD.,Tang, Y.,Zhang, XZ.,Wang, JQ.,...&yjyang22@gmail.com.(2014).Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells.BIOLOGICAL TRACE ELEMENT RESEARCH,159(42007),393—398.
MLA Jin, C,et al."Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells".BIOLOGICAL TRACE ELEMENT RESEARCH 159.42007(2014):393—398.
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