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| Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells | |
| Jin, C; Wang, FD; Tang, Y; Zhang, XZ; Wang, JQ; Yang, YJ; chanjin1980@gmail.com; yjyang22@gmail.com | |
| 2014 | |
| Source Publication | BIOLOGICAL TRACE ELEMENT RESEARCH
 |
| ISSN | 0163-4984 |
| Volume | 159Issue:42007Pages:393—398 |
| Abstract | Graphene and its derivatives are increasingly applied in nanoelectronics, biosensing, drug delivery, and biomedical applications. However, the information about its cytotoxicity remains limited. Herein, the distribution and cytotoxicity of graphene oxide (GO) and TiO2-graphene oxide composite (TiO2-GO composite) were evaluated in A549 cells. Cell viability and cell ultrastructure were measured. Our results indicated that GO could enter A549 cells and located in the cytoplasm and nucleus without causing any cell damage. TiO2 nanoparticles and GO would be separated after TiO2-GO composite entered A549 cells. TiO2-GO composite could induce cytotoxicity similar to TiO2 nanoparticles, which was probably attributed to oxidative stress. These results should be considered in the development of biological applications of GO and TiO2-GO composite. |
| Keyword | Magnetic Nanoparticles Cellular Uptake Cytotoxicity Endocytosis Toxicity Films Line |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000337284300048 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14085 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | chanjin1980@gmail.com; yjyang22@gmail.com |
| Recommended Citation GB/T 7714 | Jin, C,Wang, FD,Tang, Y,et al. Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2014,159(42007):393—398. |
| APA | Jin, C.,Wang, FD.,Tang, Y.,Zhang, XZ.,Wang, JQ.,...&yjyang22@gmail.com.(2014).Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells.BIOLOGICAL TRACE ELEMENT RESEARCH,159(42007),393—398. |
| MLA | Jin, C,et al."Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells".BIOLOGICAL TRACE ELEMENT RESEARCH 159.42007(2014):393—398. |
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