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| DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types | |
| Yang, XF; Li, J; Pei, H; Zhao, Y; Zuo, XL; Fan, CH; Huang, Q; huangqing@sinap.ac.cn | |
| 2014 | |
| Source Publication | ANALYTICAL CHEMISTRY
 |
| ISSN | 0003-2700 |
| Volume | 86Issue:6Pages:3227—3231 |
| Abstract | The direct analysis of cancerous cells provides a new way for cancer detection that obviates cell lysis and other tedious steps (e.g., enrichment, purification, and amplification steps). However, the analysis of different cell types remains challenging due to the subtle differences in cell surface features. Here, we have demonstrated nanoplasmonic differentiation of cell types by using DNA-gold nanoparticle nanoconjugates (DNA-AuNPs). Our strategy relies on cross reactive receptors (a collection of DNA-AuNPs) that are employed to bind the different cells that produce fingerprint-like patterns for each type of cell. Because of the enhanced nanoplasmonic effect of AuNPs via seeded-growth, we could effectively differentiate various cell lines, e.g., 786-O, L929, Hela, and RAW264.7, with dark-field microscopy or even naked eyes. |
| Keyword | Sensor Array Cancer-cells Protein Aptamers Nanostructures Identification Recognition Evolution Medicine Surfaces |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000333235700057 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14089 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | huangqing@sinap.ac.cn |
| Recommended Citation GB/T 7714 | Yang, XF,Li, J,Pei, H,et al. DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types[J]. ANALYTICAL CHEMISTRY,2014,86(6):3227—3231. |
| APA | Yang, XF.,Li, J.,Pei, H.,Zhao, Y.,Zuo, XL.,...&huangqing@sinap.ac.cn.(2014).DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types.ANALYTICAL CHEMISTRY,86(6),3227—3231. |
| MLA | Yang, XF,et al."DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types".ANALYTICAL CHEMISTRY 86.6(2014):3227—3231. |
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| DNA-Gold Nanoparticl（1730KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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