CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types
Yang, XF; Li, J; Pei, H; Zhao, Y; Zuo, XL; Fan, CH; Huang, Q; huangqing@sinap.ac.cn
2014
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume86Issue:6Pages:3227—3231
AbstractThe direct analysis of cancerous cells provides a new way for cancer detection that obviates cell lysis and other tedious steps (e.g., enrichment, purification, and amplification steps). However, the analysis of different cell types remains challenging due to the subtle differences in cell surface features. Here, we have demonstrated nanoplasmonic differentiation of cell types by using DNA-gold nanoparticle nanoconjugates (DNA-AuNPs). Our strategy relies on cross reactive receptors (a collection of DNA-AuNPs) that are employed to bind the different cells that produce fingerprint-like patterns for each type of cell. Because of the enhanced nanoplasmonic effect of AuNPs via seeded-growth, we could effectively differentiate various cell lines, e.g., 786-O, L929, Hela, and RAW264.7, with dark-field microscopy or even naked eyes.
KeywordSensor Array Cancer-cells Protein Aptamers Nanostructures Identification Recognition Evolution Medicine Surfaces
Indexed BySCI
Language英语
WOS IDWOS:000333235700057
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14089
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorhuangqing@sinap.ac.cn
Recommended Citation
GB/T 7714
Yang, XF,Li, J,Pei, H,et al. DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types[J]. ANALYTICAL CHEMISTRY,2014,86(6):3227—3231.
APA Yang, XF.,Li, J.,Pei, H.,Zhao, Y.,Zuo, XL.,...&huangqing@sinap.ac.cn.(2014).DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types.ANALYTICAL CHEMISTRY,86(6),3227—3231.
MLA Yang, XF,et al."DNA-Gold Nanoparticle Conjugates-Based Nanoplasmonic Probe for Specific Differentiation of Cell Types".ANALYTICAL CHEMISTRY 86.6(2014):3227—3231.
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