CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values
Su, T; Li, MD; Ma, JN; Wong, NK; Phillips, DL; mdli@huk.hk; phillips@hku.hk
2014
Source PublicationJOURNAL OF PHYSICAL CHEMISTRY B
ISSN1520-6106
Volume118Issue:47Pages:13458—13467
AbstractThe photophysics and photochemistry of norfloxacin (NF) have been investigated in aqueous solutions of different pH using femtosecond transient absorption spectroscopy (fs-TA). Resonance Raman spectroscopic experiments on NF have also been conducted in aqueous solutions of different pH to characterize the vibrational and structural information on the initial forms of NF. The experimental results in combination with density functional theory calculations of the key intermediates help us to elucidate the early events for NF after photoexcitation in aqueous solutions with varying pH values. The fs-TA results indicate that NF mainly underwent photophysical processes on the early delay time scale (before 3 ns), and no photochemical reactions occurred on this time scale. Specifically, after the irradiation of NF, the molecule reaches a higher excited singlet S-n and then decays to the lowest-lying excited singlet state S-1 followed by intersystem crossing to transform into the lowest-lying triplet state T-1 with a high efficiency, with an exception that there is a lower efficiency observed in basic aqueous solution due to the generation of an intramolecular electron transfer as an additional pathway to waste energy.
KeywordFluoroquinolone Antibiotics Steady-state Comet Assay Photochemistry Media Photosensitization Photoreactivity Lomefloxacin Nanosecond Behavior
Indexed BySCI
Language英语
WOS IDWOS:000345722900020
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14138
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authormdli@huk.hk; phillips@hku.hk
Recommended Citation
GB/T 7714
Su, T,Li, MD,Ma, JN,et al. Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2014,118(47):13458—13467.
APA Su, T.,Li, MD.,Ma, JN.,Wong, NK.,Phillips, DL.,...&phillips@hku.hk.(2014).Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values.JOURNAL OF PHYSICAL CHEMISTRY B,118(47),13458—13467.
MLA Su, T,et al."Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values".JOURNAL OF PHYSICAL CHEMISTRY B 118.47(2014):13458—13467.
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