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| Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values | |
| Su, T; Li, MD; Ma, JN; Wong, NK; Phillips, DL; mdli@huk.hk; phillips@hku.hk | |
| 2014 | |
| Source Publication | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| ISSN | 1520-6106 |
| Volume | 118Issue:47Pages:13458—13467 |
| Abstract | The photophysics and photochemistry of norfloxacin (NF) have been investigated in aqueous solutions of different pH using femtosecond transient absorption spectroscopy (fs-TA). Resonance Raman spectroscopic experiments on NF have also been conducted in aqueous solutions of different pH to characterize the vibrational and structural information on the initial forms of NF. The experimental results in combination with density functional theory calculations of the key intermediates help us to elucidate the early events for NF after photoexcitation in aqueous solutions with varying pH values. The fs-TA results indicate that NF mainly underwent photophysical processes on the early delay time scale (before 3 ns), and no photochemical reactions occurred on this time scale. Specifically, after the irradiation of NF, the molecule reaches a higher excited singlet S-n and then decays to the lowest-lying excited singlet state S-1 followed by intersystem crossing to transform into the lowest-lying triplet state T-1 with a high efficiency, with an exception that there is a lower efficiency observed in basic aqueous solution due to the generation of an intramolecular electron transfer as an additional pathway to waste energy. |
| Keyword | Fluoroquinolone Antibiotics Steady-state Comet Assay Photochemistry Media Photosensitization Photoreactivity Lomefloxacin Nanosecond Behavior |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000345722900020 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14138 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | mdli@huk.hk; phillips@hku.hk |
| Recommended Citation GB/T 7714 | Su, T,Li, MD,Ma, JN,et al. Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2014,118(47):13458—13467. |
| APA | Su, T.,Li, MD.,Ma, JN.,Wong, NK.,Phillips, DL.,...&phillips@hku.hk.(2014).Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values.JOURNAL OF PHYSICAL CHEMISTRY B,118(47),13458—13467. |
| MLA | Su, T,et al."Femtosecond Transient Absorption Spectroscopy Study of the Early Events of Norfloxacin in Aqueous Solutions with Varying pH Values".JOURNAL OF PHYSICAL CHEMISTRY B 118.47(2014):13458—13467. |
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