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Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules
Zhao, B; Shen, JL; Chen, SX; Wang, DF; Li, F; Mathur, S; Song, SP; Fan, CH; spsong@sinap.ac.cn
2014
Source PublicationCHEMICAL SCIENCE
ISSN2041-6520
Volume5Issue:11Pages:4460—4466
AbstractSurface-enhanced Raman scattering (SERS) has recently been used to design novel nanoprobes called "SERS tags" which hold great promise for the fields of biosensing and nanomedicine. More recent advances have shed new light on the synthesis of uniform nanostructures with interior nanogaps for stable SERS enhancement. However, producing interior nanogap-based SERS nanotags directly and controllably with strong and stable multiplex SERS signals as well as developing a multiplex analytical platform to recognize different types of bioactive molecules still remain highly challenging. To address this challenge, we herein develop a novel approach for the direct synthesis of nanogap-based universal SERS nanotags by mediating poly-adenine (polyA) and encoding non-fluorescent small molecules. The universal nanotags were then functionalized by different types of biological probes and used as SERS nanoprobes to recognize various bioactive molecules. To the best of our knowledge, this is the first example of using SERS nanotags to develop a simultaneous multianalysis platform for all of the major types of bioactive analytes, including nucleic acids, proteins and small molecules. Furthermore, the nanotags show great promise for fluorescence-SERS bimodal bioanalysis and bioimaging.
KeywordEnhanced Raman-scattering Single-stranded-dna Optical Nanoprobes Cancer-detection Ovarian-cancer Nanoparticles Hybridization Spectroscopy Nucleosides Biomarkers
Indexed BySCI
Language英语
WOS IDWOS:000343004300043
Citation statistics
Cited Times:89[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14166
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorspsong@sinap.ac.cn
Recommended Citation
GB/T 7714
Zhao, B,Shen, JL,Chen, SX,et al. Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules[J]. CHEMICAL SCIENCE,2014,5(11):4460—4466.
APA Zhao, B.,Shen, JL.,Chen, SX.,Wang, DF.,Li, F.,...&spsong@sinap.ac.cn.(2014).Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules.CHEMICAL SCIENCE,5(11),4460—4466.
MLA Zhao, B,et al."Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules".CHEMICAL SCIENCE 5.11(2014):4460—4466.
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