CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration
Wu, ZY; Tang, TT; Guo, H; Tang, SC; Niu, YF; Zhang, J; Zhang, WJ; Ma, R; Su, JC; Liu, CS; Wei, J; biomaterbone@163.com; jiewei7860@sina.com
2014
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume120Pages:38—46
AbstractMesoporous magnesium silicate (m-MS) was synthesized, and the in vitro degradability, bioactivity and primary cell responses to m-MS were investigated. The results suggested that the m-MS with mesoporous channels of approximately 5 nm possessed the high specific surface area of 451.0 m(2)/g and a large specific pore volume of 0.41 cm(3)/g compared with magnesium silicate (MS) without mesopores of 75 m2/g and 0.21 cm(3)/g, respectively. The m-MS was able to absorb a large number of water, with water absorption of 74% compared with 26% for MS. The m-MS was also degradable in a Tris-HCI solution, with a weight loss ratio of 40 wt% after a 70-day immersion period. The m-MS exhibited good in vitro bioactivity, inducing apatite formation on its surfaces after soaking in simulated body fluid (SBF) at a faster rate than observed for MS. The m-MS surface clearly promoted the proliferation and differentiation of MC3T3-E1 cells, and their normal cell morphology indicated excellent cytocompatibility. This study suggested that mesoporous magnesium silicate with a high specific surface area and pore volume had suitable degradability and good bioactivity and biocompatibility, making it an excellent candidate biomaterial for the induction of bone regeneration. (C) 2014 Elsevier B.V. All rights reserved.
KeywordDrug-delivery Glass Scaffolds Nanoparticles Enhancement Bioceramics Stability Ceramics Chitosan Release Alloy
Indexed BySCI
Language英语
WOS IDWOS:000339774500006
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14191
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorbiomaterbone@163.com; jiewei7860@sina.com
Recommended Citation
GB/T 7714
Wu, ZY,Tang, TT,Guo, H,et al. In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,120:38—46.
APA Wu, ZY.,Tang, TT.,Guo, H.,Tang, SC.,Niu, YF.,...&jiewei7860@sina.com.(2014).In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration.COLLOIDS AND SURFACES B-BIOINTERFACES,120,38—46.
MLA Wu, ZY,et al."In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration".COLLOIDS AND SURFACES B-BIOINTERFACES 120(2014):38—46.
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