CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
Li, B; Zhang, XY; Yang, JZ; Zhang, YJ; Li, WX; Fan, CH; Huang, Q; huangqing@sinap.ac.cn
2014
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume9Pages:4697—4707
AbstractIn this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.
KeywordChemical-modification Cancer-therapy Drug-delivery In-vivo Nanoparticle Biocompatibility Internalization
Indexed BySCI
Language英语
WOS IDWOS:000343164700001
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14194
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorhuangqing@sinap.ac.cn
Recommended Citation
GB/T 7714
Li, B,Zhang, XY,Yang, JZ,et al. Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:4697—4707.
APA Li, B.,Zhang, XY.,Yang, JZ.,Zhang, YJ.,Li, WX.,...&huangqing@sinap.ac.cn.(2014).Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,4697—4707.
MLA Li, B,et al."Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):4697—4707.
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