CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles
Bai, R; Zhang, LL; Liu, YL; Li, B; Wang, LM; Wang, P; Autrup, H; Beer, C; Chen, CY; bair@nanoctr.cn; zhanglili@sinap.ac.cn; liuy@nanoctr.cn; libai@ihep.ac.cn; wangliming@ihep.ac.cn; wangp@nanoctr.cn; ha@mil.au.dk; cbee@mil.au.dk; chenchy@nanoctr.cn
2014
Source PublicationTOXICOLOGY LETTERS
ISSN0378-4274
Volume226Issue:1Pages:70—80
AbstractHealth impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were exposed to CuNPs in three doses (1, 10, 40 mg/kg bw). The body weight of mice decreased significantly in the 10 and 40 mg/kg group (p < 0.05) but recovered slightly within exposure duration. Inductively coupled plasma mass spectrometry (ICP-MS) analysis showed that CuNPs could enter the brain. Altered distribution of some important metal elements was observed by synchrotron radiation X-ray fluorescence (SRXRF). H&E staining and immunohistochemical analysis showed that CuNPs produced damages to nerve cells and astrocyte might be the one of the potential targets of CuNPs. The changes of neurotransmitter levels in different brain regions demonstrate that the dysfunction occurred in exposed groups. These data indicated that CuNPs could enter the brain after nasal inhalation and induced damages to the central nervous system (CNS). Integration of effective analytical techniques for systematic investigations is a promising direction to better understand the biological activities of nanomaterials. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
KeywordX-ray-fluorescence Central-nervous-system In-vivo Sized Copper Caenorhabditis-elegans Oxide Nanoparticles Nasal Instillation Alzheimers-disease Tio2 Nanoparticles Model Organism
Indexed BySCI
Language英语
WOS IDWOS:000332409000010
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14198
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorbair@nanoctr.cn; zhanglili@sinap.ac.cn; liuy@nanoctr.cn; libai@ihep.ac.cn; wangliming@ihep.ac.cn; wangp@nanoctr.cn; ha@mil.au.dk; cbee@mil.au.dk; chenchy@nanoctr.cn
Recommended Citation
GB/T 7714
Bai, R,Zhang, LL,Liu, YL,et al. Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles[J]. TOXICOLOGY LETTERS,2014,226(1):70—80.
APA Bai, R.,Zhang, LL.,Liu, YL.,Li, B.,Wang, LM.,...&chenchy@nanoctr.cn.(2014).Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles.TOXICOLOGY LETTERS,226(1),70—80.
MLA Bai, R,et al."Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles".TOXICOLOGY LETTERS 226.1(2014):70—80.
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