CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures
Song, B; Sun, Q; Li, HK; Ge, BS; Pan, JS; Wee, ATS; Zhang, Y; Huang, SH; Zhou, RH; Gao, XY; Huang, F; Fang, HP; bosong@sinap.ac.cn; xingyugao@sinap.ac.cn; fhuang@upc.edu.cn
2014
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume53Issue:25Pages:6357—6363
AbstractA combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.
KeywordAlzheimers-disease Alpha-synuclein Program Package Accumulation Dialysis Binding Hydroxide Energy Virus Brain
Indexed BySCI
Language英语
WOS IDWOS:000337095900004
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/14206
Collection中科院上海应用物理研究所2011-2019年
Corresponding Authorbosong@sinap.ac.cn; xingyugao@sinap.ac.cn; fhuang@upc.edu.cn
Recommended Citation
GB/T 7714
Song, B,Sun, Q,Li, HK,et al. Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(25):6357—6363.
APA Song, B.,Sun, Q.,Li, HK.,Ge, BS.,Pan, JS.,...&fhuang@upc.edu.cn.(2014).Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(25),6357—6363.
MLA Song, B,et al."Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.25(2014):6357—6363.
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