Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures | |
| Song, B; Sun, Q; Li, HK; Ge, BS; Pan, JS; Wee, ATS; Zhang, Y; Huang, SH; Zhou, RH; Gao, XY; Huang, F; Fang, HP; bosong@sinap.ac.cn; xingyugao@sinap.ac.cn; fhuang@upc.edu.cn | |
| 2014 | |
| Source Publication | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| ISSN | 1433-7851 |
| Volume | 53Issue:25Pages:6357—6363 |
| Abstract | A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone. |
| Keyword | Alzheimers-disease Alpha-synuclein Program Package Accumulation Dialysis Binding Hydroxide Energy Virus Brain |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000337095900004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/14206 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Corresponding Author | bosong@sinap.ac.cn; xingyugao@sinap.ac.cn; fhuang@upc.edu.cn |
| Recommended Citation GB/T 7714 | Song, B,Sun, Q,Li, HK,et al. Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(25):6357—6363. |
| APA | Song, B.,Sun, Q.,Li, HK.,Ge, BS.,Pan, JS.,...&fhuang@upc.edu.cn.(2014).Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(25),6357—6363. |
| MLA | Song, B,et al."Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.25(2014):6357—6363. |
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