CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Long-Term Effects of Nanoparticles on Nutrition and Metabolism
Chen, N; Wang, H; Huang, Q; Li, J; Yan, J; He, DN; Fan, CH; Song, HY;;
Source PublicationSMALL
AbstractNanoparticles have shown great potential in biological and biomedical applications due to their distinct physical and chemical properties. In the meanwhile, the biosafety of nanoparticles has also raised intense concerns worldwide. To address such concerns, great efforts have been made to examine short-term effects of nanoparticles on cell survival and proliferation. More recently, exploration of long-term effects of nanomaterials, particularly those with promising biomedical applications in vivo, has aroused significant interest. For example, gold nanoparticles (AuNPs) are generally considered non-toxic to cell growth, whereas recent studies suggest that AuNPs might have long-term effects on cellular metabolism and energy homeostasis. In this Review, recent advances in this direction are summarized. Further, possible mechanisms under which nanoparticles regulate metabolic signaling pathways, potential long-term effects on cellular anabolic or catabolic processes, and their implications in human health and metabolic disorders are discussed.
KeywordTitanium-dioxide Nanoparticles Induced Oxidative Stress Induce Autophagosome Accumulation Iron-oxide Nanoparticles Mesenchymal Stem-cells Human Lung-cells Gold Nanoparticles Drosophila-melanogaster Insulin-resistance In-vivo
Indexed BySCI
WOS IDWOS:000342687700001
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GB/T 7714
Chen, N,Wang, H,Huang, Q,et al. Long-Term Effects of Nanoparticles on Nutrition and Metabolism[J]. SMALL,2014,10(18):3603—3611.
APA Chen, N.,Wang, H.,Huang, Q.,Li, J.,Yan, J.,...& Effects of Nanoparticles on Nutrition and Metabolism.SMALL,10(18),3603—3611.
MLA Chen, N,et al."Long-Term Effects of Nanoparticles on Nutrition and Metabolism".SMALL 10.18(2014):3603—3611.
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